This application is a request for continuation of support for a pre-doctoral Training Program in Virology at Yale University. The goal is to provide multidisciplinary research training to predoctoral students in the molecular biology of viruses, virus-host interactions, and pathogenesis in human viral diseases. This is expected to provide the intellectual and research foundations necessary for productive careers in virology-related disciplines in academia, industry, and government. The program offers training in virtually all aspects of modern virology including viral genetics, the molecular, cellular and structural biology of viruses, adaptive and innate immune response to viruses, virus-host interactions at the cellular and organismal levels as well as translational research towards the treatment of viral diseases. The program is co-directed by Drs. Priti Kumar and Walther Mothes, and a 5 member Advisory Committee. The program has been strengthened by the addition of new Faculty trainers and courses to cover emerging critical areas of virology. As a group, the 22 trainers have an outstanding record of research accomplishment and training and many are national or international leaders in their fields. These trainers have primary appointments in 14 different Yale departments and currently have 51 predoctoral virology trainees working in their labs. Students enter the program through the Combined Program in Biological and Biomedical Sciences (BBS). The BBS unites nearly 375 faculty in basic biological and biomedical sciences at the Yale Medical School, Science Hill on the main University Campus, and the newly developed West Campus. Admission is granted to students with outstanding academic record with particular attention to research experience. The Faculty makes extensive efforts to attract and retain trainees from diverse backgrounds, particularly under- represented minority groups. The program is supported by strong institutional commitment to graduate training. Predoctoral training leading to the Ph.D. degree involves formal course work and laboratory rotations in the first year. This provides a solid and broad conceptual foundation and experimental training in microbiology, immunology, cell biology, genetics, as well as other areas of biology. Students select a research advisor at the end of the first year and defend a research proposal in a qualifying exam at the beginning of the second year. A Thesis Committee monitors student progress throughout the thesis research process. Intensive training in the methods, logic, and responsible conduct of research are supplemented with a wide array of opportunities for teaching and scientific interactions. The median time to obtain the Ph.D. degree is 5.4 years. This application requests funding to continue support for four predoctoral trainees in each year, with each trainees supported by this grant for a maximum of two years.

Public Health Relevance

The Pre-doctoral Training in Virology at Yale University supports the education and training of the next generation of virology research scientists. Graduates from this program go on to leading positions in academia, industry and government, where they contribute to finding new approaches to prevent and combat viral diseases.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Coomes, Stephanie
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Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
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Molony, Ryan D; Malawista, Anna; Montgomery, Ruth R (2018) Reduced dynamic range of antiviral innate immune responses in aging. Exp Gerontol 107:130-135
Vallery, Tenaya K; Withers, Johanna B; Andoh, Joana A et al. (2018) Kaposi's Sarcoma-Associated Herpesvirus mRNA Accumulation in Nuclear Foci Is Influenced by Viral DNA Replication and Viral Noncoding Polyadenylated Nuclear RNA. J Virol 92:
Wong, Victor C; Bass, Victor L; Bullock, M Elise et al. (2018) NF-?B-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise. Cell Rep 22:585-599
Beloor, Jagadish; Maes, Nyree; Ullah, Irfan et al. (2018) Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus. Cell Host Microbe 23:549-556.e3
Iwasaki, Akiko; Foxman, Ellen F; Molony, Ryan D (2017) Early local immune defences in the respiratory tract. Nat Rev Immunol 17:7-20
Goldberg, Emily L; Asher, Jennifer L; Molony, Ryan D et al. (2017) ?-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep 18:2077-2087
Lipovsky, Alex; Erden, Asu; Kanaya, Eriko et al. (2017) The cellular endosomal protein stannin inhibits intracellular trafficking of human papillomavirus during virus entry. J Gen Virol 98:2821-2836
Khoury-Hanold, William; Yordy, Brian; Kong, Philip et al. (2016) Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. Cell Host Microbe 19:788-99
Pillai, Padmini S; Molony, Ryan D; Martinod, Kimberly et al. (2016) Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 352:463-6
Liu, Shan; Jackson, Andrew; Beloor, Jagadish et al. (2015) Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice. Hum Gene Ther 26:622-34

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