This program requests 4 predoctoral positions for training in immune system development and regulation (ISDR). The program includes 26 trainers with expertise in the development and regulation of the immune system, who are a subset of the Immunology Graduate Group (IGG) at the University of Pennsylvania. This discipline-based training program has a >35-year record of outstanding training. The academic elements of the IGG curriculum form the core experiences for trainees in the ISDR program, and reflect a proven yet evolving mixture of coursework, laboratory rotations, research presentations, and thesis research. These are enriched by a large array of additional activities that foster scientific exchange and discussion, including ongoing activities such as our annual 2.5-day retreat, weekly colloquium, and weekly work-in-progress series, as well as an agreement that affords training with adjunct faculty on the NIH Bethesda campus. The assembled trainers for this grant have highly productive training records in the area of immune system development and regulation, as well as over $75M in annual research support to assure quality and continuity of the training experience. The breadth and strength of the assembled training faculty affords a diverse array of potential trainee mentors. The program has over 100 applicants annually, which are a subset of over 1,000 applicants to biomedical graduate studies at the University of Pennsylvania. The IGG program recruits between 8 to 12 PhD and 2 to 5 MD-PhD trainees per year, yielding a student body of ~60 students, and the ISDR supports a subset of the upper 15% of these. The ISDR focuses specifically on students/faculty whose research is directed towards understanding the development and regulation of the immune system and immune responses. In this regard, the ISDR fosters research training that bears directly on control and manipulation of the immune system in health and disease.

Public Health Relevance

Lymphocytes are cells of the immune system that govern responses to pathogens and vaccines, and whose failed regulation can lead to inflammatory and autoimmune diseases. This program will prepare outstanding scientists to study lymphocyte development and regulation. This will ultimately foster advances in vaccine development and organ transplantation, as well as therapies for autoimmune disease and cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055428-14
Application #
9279049
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2003-06-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
14
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Pardi, Norbert; Hogan, Michael J; Naradikian, Martin S et al. (2018) Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses. J Exp Med 215:1571-1588
Wu, Glendon S; Bassing, Craig H (2018) The ESCRT protein CHMP5 escorts ?? T cells through positive selection. Cell Mol Immunol 15:654-656
Ecker, Christopher; Riley, James L (2018) Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition. Cell Metab 28:190-195
Ecker, Christopher; Guo, Lili; Voicu, Stefana et al. (2018) Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep 23:741-755
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Mowel, Walter K; McCright, Sam J; Kotzin, Jonathan J et al. (2017) Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity 47:435-449.e8
Sindhava, Vishal J; Oropallo, Michael A; Moody, Krishna et al. (2017) A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest 127:1651-1663

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