In the present application, we seek renewed support for the Immunology Research Training Program at the University of California, Irvine (UCI). The objective of the Immunology Research Training Program is to train scientists to study the role of immune system in infection, autoimmunity, neuro-inflammation and cancer. These research areas are addressed by the 20 mentors and 3 junior preceptors of the UCI Institute for Immunology (IFI), which, under the leadership of Dr. Eric Pearlman, will provide the administrative and academic core for this training program. The IFI faculty will capitalize on the strengths of the existing Cellular and Molecular Biosciences (CMB) a n d n e u r o s c i e n c e u m b r e l l a graduate programs. The strengths of the UCI Immunology Research Training Program include: 1) The highly structured training program and scientifically strong environment at UCI IFI; 2) The leadership and experience of the Program Director/PI, Dr. Eric Pearlman, former director of the NIH T32-supported Visual Sciences Program at Case Western Reserve University; 3) the Preceptors/Mentors, who are established investigators in wide-ranging areas of immunology; 4) the existing pool of predoctoral trainees, recruited from top-tier institutions, and the success of the Immunology Research Training Program in its first four years of existence in recruiting and attracting individuals from diverse populations; 5) The strong training record of UCI Immunology Research Training Program in its 10 years of existence, during which 1 9 pre-doctoral trainees and 2 postdoctoral trainees were supported and have been highly productive. For this third period of support (2016-2020), funding is requested for 4 pre-docs and 2 post-doctoral slots. Importantly, the Graduate Division at UCI will also provide 1 additional slot upon funding of this application; thus, there is potential for 5 pre-doctoral students to be supported for immunology research. The existing strengths in immunology at UCI will be embellished and provide career opportunities for trainees in academia and industry.

Public Health Relevance

There is an increased appreciation that in addition to infection, immune responses have a critical role in development and severity of cancer and neurodegenerative diseases. The Immunology Research Training Program at UCI seeks to train and develop the next generation of outstanding immunologists to work on these areas. Trainees will be at the forefront of discovery and application of the immune system to ameliorate human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI060573-11
Application #
9148639
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
2004-07-01
Project End
2021-07-31
Budget Start
2016-08-18
Budget End
2017-07-31
Support Year
11
Fiscal Year
2016
Total Cost
$116,004
Indirect Cost
$6,858
Name
University of California Irvine
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617
Chiu, Honyin; Jackson, Leandra V; Oh, Kwon Ik et al. (2018) The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes. J Immunol :
Kastenschmidt, Jenna M; Avetyan, Ileen; Villalta, S A (2018) Characterization of the Inflammatory Response in Dystrophic Muscle Using Flow Cytometry. Methods Mol Biol 1687:43-56
Gov, Lanny; Schneider, Christine A; Lima, Tatiane S et al. (2017) NLRP3 and Potassium Efflux Drive Rapid IL-1? Release from Primary Human Monocytes during Toxoplasma gondii Infection. J Immunol 199:2855-2864
Chiu, Honyin; Mallya, Sharmila; Nguyen, Phuongthao et al. (2017) The Selective Phosphoinoside-3-Kinase p110? Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. Front Immunol 8:747
Catalan-Dibene, Jovani; Vazquez, Monica I; Luu, Van Phi et al. (2017) Identification of IL-40, a Novel B Cell-Associated Cytokine. J Immunol 199:3326-3335
Parker, Ian; Evans, Katrina T; Ellefsen, Kyle et al. (2017) Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep 7:11029
Dong, Tobias X; Othy, Shivashankar; Greenberg, Milton L et al. (2017) Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife 6:
Diaz-Ochoa, Vladimir E; Lam, Diana; Lee, Carlin S et al. (2016) Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell Host Microbe 19:814-25
So, Lomon; Lee, Jongdae; Palafox, Miguel et al. (2016) The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal 9:ra57
Pone, Egest J; Lam, Tonika; Lou, Zheng et al. (2015) B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol 194:3065-78

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