Infectious diseases continue to represent the most important global health threat to mankind;yet inadequate numbers of physician-scientists are being trained who are prepared for academic research careers that can impact our understanding of the pathogenesis and treatment of infectious diseases. We propose the continuation of the UT Southwestern (UTSW) Infectious Diseases postdoctoral training program to train physician-scientists to perform cutting edge basic science research related to host-pathogen interactions. This program provides training for Adult and Pediatric Infectious Diseases Fellows (as well as Pulmonary and Digestive and Liver Fellows who are interested in host-pathogen interactions). The overall goal of this program is to train physician-scientists for successful careers in academic infectious diseases-related research. Specific goals of the research training are for trainees to: (1) develop proficiency in state-of-the art- techniques relevant to infectious diseases research in the area of host-pathogen interactions;(2) gain expertise in a relevant area of biomedical science, such a microbial genetics, immunology, cell biology, biochemistry, or pharmacology;(3) gain expertise and independence in generating strong research hypotheses and in rigorous experimental design and data interpretation;and (4) complete a mentored research project that leads to one or more first-authored peer reviewed publications and NIH career development award applications. These goals will be accomplished by a combination of (1) intensive supervised basic science research experience in the laboratories of our 22 program training faculty (all of whom are outstanding NIH-funded scientists performing exciting work in the field of host-pathogen interactions);(2) a comprehensive didactic curriculum that includes required courses and electives in biomedical sciences, ethics, statistics, and career development;(3) active mentoring and career development by the primary mentor and thesis committee members;and (4) the opportunity to train in a highly interactive and stimulating interdisciplinary scientific environment. This comprehensive and multi-faceted approach will result in the training of post-doctoral fellows in Infectious Diseases research with strong potential to succeed in academic research careers and strong potential to perform basic science research that will impact the prevention and/or treatment of infectious diseases.

Public Health Relevance

The goal of the UT Southwestern Infectious Diseases Training Program is to provide Adult and Pediatric Infectious Diseases Fellows (and other clinical fellows with a research interest in Infectious Diseases) with in-depth research training i the area of the biology of pathogens and host-pathogen interactions. This training will prepare them for careers as physician scientists in academic medicine and enable them to discover new knowledge that will advance our understanding of the causes and treatment of infectious diseases. To achieve this goal, the program provides an intensive 2-3 year experience in basic science research supplemented by formal didactic instruction in biomedical sciences, career development, and ethics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI070116-07
Application #
8490280
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
2006-07-01
Project End
2017-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
7
Fiscal Year
2013
Total Cost
$128,699
Indirect Cost
$9,533
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
De Nisco, Nicole J; Rivera-Cancel, Giomar; Orth, Kim (2018) The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues. MBio 9:
De Nisco, Nicole J; Orth, Kim; VanHook, Annalisa M (2017) Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells. Sci Signal 10:
De Nisco, Nicole J; Kanchwala, Mohammed; Li, Peng et al. (2017) The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways. Sci Signal 10:
Robinson, Christopher M; Wang, Yao; Pfeiffer, Julie K (2017) Sex-Dependent Intestinal Replication of an Enteric Virus. J Virol 91:
Franco, Luis H; Nair, Vidhya R; Scharn, Caitlyn R et al. (2017) The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense. Cell Host Microbe 22:421-423
Sumpter Jr, Rhea; Sirasanagandla, Shyam; Fernández, Álvaro F et al. (2016) Fanconi Anemia Proteins Function in Mitophagy and Immunity. Cell 165:867-81
Chen, Qiuyue; Denard, Bray; Lee, Ching-En et al. (2016) Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Mol Cell 63:567-578
Joslin, Stephanie N; Pybus, Christine; Labandeira-Rey, Maria et al. (2015) A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors. Infect Immun 83:146-60
Wei, Yongjie; An, Zhenyi; Zou, Zhongju et al. (2015) The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. Elife 4:
Denard, Bray; Pavia-Jimenez, Andrea; Chen, Weina et al. (2015) Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome. PLoS One 10:e0129233

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