Abstract

Purpose and Program Proposal: the purpose of this continuation proposal is to provide training in bone and cartilage research to pre-doctoral trainees in Bioengineering and to postdoctoral, post-residency trainees in Orthopaedic Surgery in order to prepare both types of trainees for academic careers. In addition, it is proposed to provide a meaningful research experience to medical student trainees as a means of attracting young, eager minds to an academic career early in their training before residency training begins. Research areas include the biology of bone growth, repair, and maintenance including origin of osteoprogenitor cells, physiological response of isolated bone cells to mechanical strain, mechanism of action or mechanical and electrical perturbation of bone and cartilage cells, characterization of transmembrane molecules (integrins) and their role as mechanical receptors; bone cell growth into porous implants; mechanisms of bioactivity produced by calcium phosphate ceramics; and the biocompatibility of particulate debris and its inflammatory response.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007132-25
Application #
2909744
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Panagis, James S
Project Start
1976-07-01
Project End
2001-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
25
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Orthopedics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Qu, Feini; Stoeckl, Brendan D; Gebhard, Peter M et al. (2018) A Wearable Magnet-Based System to Assess Activity and Joint Flexion in Humans and Large Animals. Ann Biomed Eng 46:2069-2078
Qu, Feini; Li, Qing; Wang, Xiao et al. (2018) Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Sci Rep 8:3295
Kwon, Mi Y; Vega, Sebastián L; Gramlich, William M et al. (2018) Dose and Timing of N-Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels. Adv Healthc Mater 7:e1701199
Vega, Sebastián L; Kwon, Mi Y; Song, Kwang Hoon et al. (2018) Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments. Nat Commun 9:614
Kegelman, Christopher D; Mason, Devon E; Dawahare, James H et al. (2018) Skeletal cell YAP and TAZ combinatorially promote bone development. FASEB J 32:2706-2721
Sperry, Megan M; Kartha, Sonia; Granquist, Eric J et al. (2018) Inter-subject FDG PET Brain Networks Exhibit Multi-scale Community Structure with Different Normalization Techniques. Ann Biomed Eng 46:1001-1012
Freedman, Benjamin R; Rodriguez, Ashley B; Leiphart, Ryan J et al. (2018) Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission. Sci Rep 8:10854
Sperry, Megan M; Yu, Ya-Hsin; Welch, Rachel L et al. (2018) Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model. Sci Rep 8:13894
Sperry, Megan M; Ita, Meagan E; Kartha, Sonia et al. (2017) The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights From the Facet and Temporomandibular Joints. J Biomech Eng 139:
Bansal, Sonia; Keah, Niobra M; Neuwirth, Alexander L et al. (2017) Large Animal Models of Meniscus Repair and Regeneration: A Systematic Review of the State of the Field. Tissue Eng Part C Methods 23:661-672

Showing the most recent 10 out of 85 publications