(from the application): The goal of our program is to provide high quality research training in the biomedical investigation of the rheumatic diseases. We have developed a research training environment conducive to the proper nurturing of young scientists interested in the rheumatic diseases. Two pathways are proposed: Training of M.D. rheumatology fellows, and training of Ph.D. scientists. Both will be exposed to basic investigation of a scientific question by hands-on experience and to clinical rheumatology. Our research program is centered on five major areas: 1) Animal models of rheumatic disease; 2) Autoimmunity and tolerance; 3) Inflammation and complement; 4) Immunoregulation and host defense; 5) Receptor signaling. Preceptors with outstanding track records in training and stable funding from 3 distinct units at Washington University are participating. This includes the Rheumatology Division in the Department of Medicine, the Division of Allergy, Immunology, and Rheumatology in the Department of Pediatrics, and the Center for Immunology. Both physician-scientists (M.D. and M.D.-Ph.D.) and basic scientist (Ph.D.) preceptors form the Program faculty who are dedicated to training the next generation of basic scientists interested in the immunobiology of the rheumatic diseases.
| Kulkarni, Hrishikesh S; Liszewski, M Kathryn; Brody, Steven L et al. (2018) The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target? J Allergy Clin Immunol 141:1582-1586.e1 |
| Kulkarni, Hrishikesh S; Witt, Chad A (2018) Voriconazole in lung transplant recipients - how worried should we be? Am J Transplant 18:5-6 |
| Kulkarni, Hrishikesh S; Elvington, Michelle L; Perng, Yi-Chieh et al. (2018) Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death. Am J Respir Cell Mol Biol : |
| Hoegl, Sandra; Ehrentraut, Heidi; Brodsky, Kelley S et al. (2017) NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol 101:471-480 |
| Liszewski, M Kathryn; Elvington, Michelle; Kulkarni, Hrishikesh S et al. (2017) Complement's hidden arsenal: New insights and novel functions inside the cell. Mol Immunol 84:2-9 |
| Elvington, Michelle; Liszewski, M Kathryn; Bertram, Paula et al. (2017) A C3(H20) recycling pathway is a component of the intracellular complement system. J Clin Invest 127:970-981 |
| Schmid, Edward T; Pang, Iris K; Carrera Silva, Eugenio A et al. (2016) AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity. Elife 5: |
| Elvington, Michelle; Liszewski, M Kathryn; Atkinson, John P (2016) Evolution of the complement system: from defense of the single cell to guardian of the intravascular space. Immunol Rev 274:9-15 |
| Speer, Scott D; Li, Zhi; Buta, Sofija et al. (2016) ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun 7:11496 |
| Miner, Jonathan J; Diamond, Michael S (2016) Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier. Curr Opin Immunol 38:18-23 |
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