The Immunodermatology Fellowship Training Program, based in the Dermatology Department at U.T. Southwestern, was established in 1976 and it has received continuous support from the National Research Service Award (NRSA) program for 15 years. Support for an additional 5 years is requested. Our purpose is to provide a stimulating, resource-rich, and critical environment in which postdoctoral M.D.'s, Ph.D.'s and predoctoral students of all races and ethnic backgrounds, who are interested in the prospect of academic careers dedicated to examining mechanisms of immunologically mediated skin disease, can develop the knowledge and skills that permit eventual establishment of independent programs of basic and/or clinical immunodermatologic investigation. The immunodermatology fellowship training program has since its inception been supported by immunologists from several departments at U.T. Southwestern. These individuals have a strong established record of collaboration on issues of cutaneous biology and disease. At present 10 individuals from 5 departments (Dermatology, Internal Medicine, Pathology, Microbiology, Cell Biology/Neurosciences) have come together as the faculty on this application. An additional strength has been the long- standing and close interaction that its faculty has maintained with the Immunology Graduate Studies Program at U.T. Southwestern. Significant changes have occurred in this training program since its last competitive renewal. The former Program Director, Dr. Robert E. Tigelaar, was replaced in 1990 by the current Program Director, Dr. Richard D. Sontheimer. Other changes include the departure of 2 other faculty members (Drs. Robert G. Freeman and Timothy J. Sullivan) and the addition of 3 new faculty (Drs. Kiyoshi Ariizumi, Ponciano D. Cruz, Jr. and Akira Takashima). In addition, an NIH-sponsored Skin Disease Research Core Center was established in the Dermatology Department in 1991. During the past 5 years, 30 postdoctoral fellows have received research training in our department, 11 of whom (8 M.D. is, 2 Ph.D. is and 1 M.D./Ph.D.) have bean supported by this NRSA. All but 2 of the 11 NRSA- supported individuals who were given the opportunity have completed their commitment to the NRSA program. Three of these 11 individuals currently hold faculty appointments, 1 is currently taking additional laboratory training elsewhere, 2 will be forced to leave our program prematurely because of the impending NRSA funding hiatus, and 1 has entered a private practice of dermatology. During the next 5 years, additional emphasis will be placed upon the recruitment of qualified individuals from underrepresented racial/ethnic groups.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
Zip Code
Vaughan, Melville B; Ramirez, Ruben D; Brown, Spencer A et al. (2004) A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro. Rejuvenation Res 7:99-110
Kienker, L J; Ghosh, M R; Tucker, P W (1998) Regulatory elements in the promoter of a murine TCRD V gene segment. J Immunol 161:791-804
Cheng, S T; Nguyen, T Q; Yang, Y S et al. (1996) Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. J Immunol 156:4484-91
Nguyen, T O; Capra, J D; Sontheimer, R D (1996) Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. Mol Immunol 33:379-86
Zappi, E; Sontheimer, R (1992) Clinical relevance of antibodies to Ro/SS-A and La/SS-B in subacute cutaneous lupus erythematosus and related conditions. Clin Dermatol 10:431-41
Simon, J C; Krutmann, J; Elmets, C A et al. (1992) Ultraviolet B-irradiated antigen-presenting cells display altered accessory signaling for T-cell activation: relevance to immune responses initiated in skin. J Invest Dermatol 98:66S-69S
McCauliffe, D P; Yang, Y S; Wilson, J et al. (1992) The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. J Biol Chem 267:2557-62
Sontheimer, R D; McCauliffe, D P; Zappi, E et al. (1992) Antinuclear antibodies: clinical correlations and biologic significance. Adv Dermatol 7:3-52;discussion 53
Sontheimer, R D; Lieu, T S; McCauliffe, D P (1991) Molecular characterization of the Ro/SS-A autoimmune response. Semin Dermatol 10:199-205
Gocinski, B L; Tigelaar, R E (1990) Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion. J Immunol 144:4121-8

Showing the most recent 10 out of 12 publications