Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007543-05
Application #
3532188
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1987-09-01
Project End
1993-06-30
Budget Start
1991-09-01
Budget End
1993-06-30
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Loma Linda University
Department
Type
Schools of Medicine
DUNS #
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Amaar, Yousef G; Baylink, David J; Mohan, Subburaman (2005) Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. J Bone Miner Res 20:1430-9
Mohan, Subburaman; Thompson, Garrett R; Amaar, Yousef G et al. (2002) ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. Biochemistry 41:15394-403
Amaar, Yousef G; Thompson, Garrett R; Linkhart, Thomas A et al. (2002) Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2). J Biol Chem 277:12053-60
Miyakoshi, N; Richman, C; Kasukawa, Y et al. (2001) Evidence that IGF-binding protein-5 functions as a growth factor. J Clin Invest 107:73-81
Miyakoshi, N; Qin, X; Kasukawa, Y et al. (2001) Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism. Endocrinology 142:2641-8
Miyakoshi, N; Kasukawa, Y; Linkhart, T A et al. (2001) Evidence that anabolic effects of PTH on bone require IGF-I in growing mice. Endocrinology 142:4349-56
Mohan, S; Kutilek, S; Zhang, C et al. (2000) Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone 27:471-8
Qin, X; Morales, S; Lee, K W et al. (1997) Structural and functional analysis of the 5'-flanking region of the human insulin-like growth factor binding protein (IGFBP)-4 gene. Biochim Biophys Acta 1350:136-40
Hayden, J M; Strong, D D; Baylink, D J et al. (1997) Osteogenic protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear transcripts in human osteosarcoma cells. Endocrinology 138:4240-7
Lau, K H; Song, X D; Ochi, M et al. (1996) Mitogenic action of hydrochlorothiazide on human osteoblasts in vitro: requirement for platelet-derived growth factor. Calcif Tissue Int 59:505-10

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