This is the tenth year of this research training program in Adult and Pediatric Rheumatology at New England Medical Center, Tufts University School of Medicine, supported by training grant AR-07570. An aspect of the training program is the close cooperation between Adult and Pediatric Rheumatology. Of the 17 graduates of the program, 11 now have faculty appointments in academic medical centers and 2 others are currently continuing their postdoctoral training here with other support. The goal is to provide supervised research in the laboratory or in clinical care research under the guidance of an accomplished faculty mentor, along with structured training in molecular biology, immunology, clinical trials, biostatistics, and ethical issues through courses or conferences. The research thrust in the Rheumatology/Immunology Division is the study of infectious agents, immunity and cytokines in the chronic inflammatory arthritides. A major focus is the study of Lyme arthritis, one of the few forms of chronic inflammatory arthritis in which the cause is known. With this grant renewal, research opportunities are being added in host responses to retroviruses and Epstein Barr virus. In addition, training in clinical care research through course work and clinical projects is a new part of the training program. Altogether, 9 faculty members participate in this rheumatology training program, including 4 from the Rheumatology/Immunology Division, 1 from Pediatric Rheumatology, 3 from the Basic Science Departments of Pathology, Molecular Biology and Microbiology, and 1 from the Division of Clinical Care Research. The participation of faculty members and trainees from Adult and Pediatric Rheumatology and Basic Science Departments offers a training opportunity in infection and immunity related to rheumatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007570-11
Application #
6323999
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Ader, Deborah N
Project Start
1991-07-01
Project End
2006-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
11
Fiscal Year
2001
Total Cost
$154,998
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
Sicat, Jocelyn; Sutkowski, Natalie; Huber, Brigitte T (2005) Expression of human endogenous retrovirus HERV-K18 superantigen is elevated in juvenile rheumatoid arthritis. J Rheumatol 32:1821-31
Drouin, Elise E; Glickstein, Lisa J; Steere, Allen C (2004) Molecular characterization of the OspA(161-175) T cell epitope associated with treatment-resistant Lyme arthritis: differences among the three pathogenic species of Borrelia burgdorferi sensu lato. J Autoimmun 23:281-92
Ntchobo, H; Rothermel, H; Chege, W et al. (2001) Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease. Infect Immun 69:1953-6
Glickstein, L; Edelstein, M; Dong, J Z (2001) Gamma interferon is not required for arthritis resistance in the murine Lyme disease model. Infect Immun 69:3737-43
Hsu, P N; Wolf Bryant, P; Sutkowski, N et al. (2001) Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis. J Immunol 166:3309-14
Rothermel, H; Hedges 3rd, T R; Steere, A C (2001) Optic neuropathy in children with Lyme disease. Pediatrics 108:477-81
Trollmo, C; Meyer, A L; Steere, A C et al. (2001) Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells. J Immunol 166:5286-91
Vaz, A; Glickstein, L; Field, J A et al. (2001) Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease. Infect Immun 69:7437-44
Carlson, D; Hernandez, J; Bloom, B J et al. (1999) Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis. Arthritis Rheum 42:2705-9
Chiravuri, M; Schmitz, T; Yardley, K et al. (1999) A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase. J Immunol 163:3092-9

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