This application proposes, building on the strengths developed through our Multipurpose Arthritis and Musculoskeletal Diseases Center, to develop a program of rheumatology research training that possesses leadership oversight, coordination, and course work. The goal of this application is to develop a cohesive and rational framework for training a critical mass of rheumatology investigators. The objectives of this National Research Service Award (NRSA) proposal in rheumatology research at Northwestern University Medical School (NUMS) are: 1) to provide support for the development of clinical and basic scientists, who will ultimately be capable of performing, independent, hypothesis-driven research, addressing the needs of their target patient population; 2) to protect these research trainees from clinical, and other, activities which may compete for their time; 3) to create an administrative structure to coordinate and provide leadership to their research training enterprise; 4) to provide both basic and clinical science trainees a rigorous base of classroom study in the disciplines necessary for successfully conducting research relevant to disease etiology, pathogenesis, and outcome and the provision of innovative care to patients with arthritis, musculoskeletal, and autoimmune disorders; 5) to consolidate, and therefore enhance, the adult and pediatric, basic and clinical, rheumatology research training programs at NUMS; and 6) to establish an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives. The long-term goal is to encourage bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s to pursue careers in rheumatology research, make them knowledgeable about the complex issues associated with conducting scientifically and ethically sound research, and to maximize the likelihood they will be competitive in seeking subsequent research support. The program builds on the current training initiatives in the basic sciences and in translational, public health, and health services research and on the scientific and research training experiences of the rheumatology faculty and collaborators from a wide variety of medical school departments, centers, and institutes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007611-05
Application #
6891932
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Ader, Deborah N
Project Start
2001-06-05
Project End
2006-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
5
Fiscal Year
2005
Total Cost
$171,438
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Poornima, I G; Shields, K; Kuller, L H et al. (2018) Associations of osteoprotegerin with coronary artery calcification among women with systemic lupus erythematosus and healthy controls. Lupus :961203317751060
Chalmers, Samantha A; Wen, Jing; Doerner, Jessica et al. (2018) Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus. Arthritis Res Ther 20:10
Gilbert, Abigail L; Lee, Jungwha; Song, Jing et al. (2018) Relationship Between Self-Reported Restless Sleep and Objectively Measured Physical Activity in Adults With Knee Osteoarthritis. Arthritis Care Res (Hoboken) :
Mandelin 2nd, Arthur M; Homan, Philip J; Shaffer, Alexander M et al. (2018) Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis. Arthritis Rheumatol 70:841-854
Mahieu, Mary A; Ahn, Grace E; Chmiel, Joan S et al. (2018) Serum adipokine levels and associations with patient-reported fatigue in systemic lupus erythematosus. Rheumatol Int 38:1053-1061
Gilbert, Abigail L; Lee, Jungwha; Ehrlich-Jones, Linda et al. (2018) A randomized trial of a motivational interviewing intervention to increase lifestyle physical activity and improve self-reported function in adults with arthritis. Semin Arthritis Rheum 47:732-740
Makinde, Hadijat M; Cuda, Carla M; Just, Talia B et al. (2017) Nonclassical Monocytes Mediate Secondary Injury, Neurocognitive Outcome, and Neutrophil Infiltration after Traumatic Brain Injury. J Immunol 199:3583-3591
Song, Jing; Gilbert, Abigail L; Chang, Rowland W et al. (2017) Do Inactive Older Adults Who Increase Physical Activity Experience Less Disability: Evidence From the Osteoarthritis Initiative. J Clin Rheumatol 23:26-32
Pellegrini, Christine A; Song, Jing; Semanik, Pamela A et al. (2017) Patients Less Likely to Lose Weight Following a Knee Replacement: Results From the Osteoarthritis Initiative. J Clin Rheumatol 23:355-360
Tsai, FuNien; Homan, Philip J; Agrawal, Hemant et al. (2017) Bim suppresses the development of SLE by limiting myeloid inflammatory responses. J Exp Med 214:3753-3773

Showing the most recent 10 out of 50 publications