This proposal is a competitive renewal application for a National Research Service Award Institutional Research Training Grant (T32) to further support a Multidisciplinary Rheumatology Training Program at Johns Hopkins. Over the past 4 years, the program has undergone substantial growth and outstanding trainee achievement, including publications, a high rate of faculty appointment after training, and a very high rate of acquisition of independent, peer-reviewed funding. We demonstrate that the overall trajectory of this program is steeply positive, with outstanding divisional and institutional resources available to postdoctoral fellows in rheumatology, substantial growth and enhancement of the program faculty, and a highly competitive pool of applicants (including women and under-represented minorities) that significantly exceed currently available slots. The program has very engaged and highly expert internal and external advisory committees. Members of the program faculty have a breadth of interests and expertise, and are proven mentors in the rheumatic diseases, immunology, molecular biology and genetics, cell biology, epidemiology and biostatistics. The overall goal of this program remains the development of outstanding academic rheumatologists, through rigorous instruction in research methodology and immersion in outstanding quality mentored research projects. Our training environment is focused on providing a productive clinical, basic and translational research training program. The following specific aims will be pursued: [1] Provide rigorous training in investigational methods to rheumatology postdoctoral fellows, applicable to the conduct of both clinical and basic research;[2] Utilize clinical centers of excellence to provide access to well-defined rheumatic disease patient populations, enabling fellow projects to be conducted on established patient cohorts;[3] Engage postdoctoral fellows in high caliber research projects addressing important questions under the supervision of nationally renowned faculty;[4] Integrate multi-layered mentorship for each postdoctoral fellow to accomplish productive research, independence, and development of a successful academic career;and [5] Assess, and modify (through incorporating feedback from trainees, training program faculty, and internal and external advisory committees) as needed, the outcomes of this training environment through assessing benchmarks of academic and programmatic achievement, including peer-reviewed publications, external research funding, post-training academic position, and recruitment of underrepresented minorities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR048522-09
Application #
8098848
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mancini, Marie
Project Start
2002-07-01
Project End
2013-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
9
Fiscal Year
2011
Total Cost
$326,360
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Igusa, Takeru; Hummers, Laura K; Visvanathan, Kala et al. (2018) Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer. Ann Rheum Dis 77:1179-1186
Craig, Ethan; Cappelli, Laura C (2018) Gastrointestinal and Hepatic Disease in Rheumatoid Arthritis. Rheum Dis Clin North Am 44:89-111
Adler, B L; Pezhouh, M K; Kim, A et al. (2018) Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis. J Intern Med 283:568-577
Gourh, Pravitt; Remmers, Elaine F; Boyden, Steven E et al. (2018) Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol 70:1654-1660
DiRenzo, Dana; McMahan, Zsuzsanna H; Desai, Naman S et al. (2018) Cerebral Venous Thrombosis Mimicking a Discrete Brain Mass: A Case Report and Literature Review. Case Rep Rheumatol 2018:5862912
Richardson, Carrie; Haque, Uzma Jalal (2018) Pulmonary Capillaritis in a Patient With Antisynthetase Syndrome and Anti-PL-7 Antibodies. J Clin Rheumatol :
Mecoli, Christopher A; Shah, Ami A; Boin, Francesco et al. (2018) Vascular complications in systemic sclerosis: a prospective cohort study. Clin Rheumatol 37:2429-2437
Adler, Brittany L; Christopher-Stine, Lisa (2018) Triggers of inflammatory myopathy: insights into pathogenesis. Discov Med 25:75-83
DiRenzo, Dana; Crespo-Bosque, Monica; Gould, Neda et al. (2018) Systematic Review and Meta-analysis: Mindfulness-Based Interventions for Rheumatoid Arthritis. Curr Rheumatol Rep 20:75
Antiochos, Brendan; Matyszewski, Mariusz; Sohn, Jungsan et al. (2018) IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren's syndrome. JCI Insight 3:

Showing the most recent 10 out of 61 publications