? This training program in Musculoskeletal Biology involves 15 training faculty at the University of Minnesota. The goals of this new five-year program are to: 1) to train 11 predoctoral students and 4 postdoctoral fellows for research careers as basic scientists or clinical investigators studying the causes and treatments of musculoskeletal diseases, and 2) develop an educational environment for students and postdoctoral fellows which encompasses a modern spectrum of research in musculoskeletal diseases, including basic discovery, investigation of musculoskeletal disease models and study of outcomes of standard treatments. In the past five years, the University of Minnesota has invested considerable resources in the retention and recruitment of numerous talented, energetic and collaborative investigators interested in musculoskeletal biology. The training program thus boasts a group of highly qualified research mentors in state-of-the-art research environments, and thus provides an ideal modern setting for training young research scientists. The research strengths of the training program described in this application are in the areas of bone cancer biology and treatments (Clohisy, Mantyh, McCarthy, Oursler), clinical outcomes-based research and epidemiology for orthopaedic and bone cancer treatments (Robison, Swiontkowski, Saleh), osteoarthritis and cartilage biology (Carlson, Bechtold, LaPrade, Lewis, Pluhar), and molecular mechanisms of osteoblast development (Westendorf, Mauro, Verfaillie). Support is requested for 5 positions (3 predoctoral and 2 postdoctoral) during the first year of the program and for 6 slots (4 predoctoral and 2 postdoctoral) each during years 2 through 5. Predoctoral trainees that will be eligible for this training program will be accepted into one of ten existing degree or combined degree graduate programs that involve the training faculty. Postdoctoral fellows will be recruited by individual mentors and the residency programs of the Department of Orthopaedic Surgery and College of Veterinary Medicine. The training program will be integrated and enriched by a program of seminars, journal clubs, and joint group meetings. The primary goals of the program are to attract exceptional young scientists into the field of musculoskeletal biology and to assist their intellectual and technical development into productive and independent investigators interested in the mechanisms and treatment of musculoskeletal diseases. ? ?

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Panagis, James S
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Lawrence, Rebekah L; Sessions, William C; Jensen, Megan C et al. (2018) The effect of glenohumeral plane of elevation on supraspinatus subacromial proximity. J Biomech 79:147-154
Cabelka, Christine A; Baumann, Cory W; Collins, Brittany C et al. (2018) Effects of ovarian hormones and estrogen receptor ? on physical activity and skeletal muscle fatigue in female mice. Exp Gerontol :
Lawrence, Rebekah L; Ellingson, Arin M; Ludewig, Paula M (2018) Validation of single-plane fluoroscopy and 2D/3D shape-matching for quantifying shoulder complex kinematics. Med Eng Phys 52:69-75
Smeester, Branden A; Lee, Jang-Hern; Beitz, Alvin J (2017) Influence of social interaction on nociceptive-induced changes in locomotor activity in a mouse model of acute inflammatory pain: Use of novel thermal assays. Brain Res Bull 134:47-54
Lawrence, Rebekah L; Schlangen, Dustin M; Schneider, Katelyn A et al. (2017) Effect of glenohumeral elevation on subacromial supraspinatus compression risk during simulated reaching. J Orthop Res 35:2329-2337
Aukes, Kelly; Forsman, Cynthia; Brady, Nicholas J et al. (2017) Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. PLoS One 12:e0185736
Claeson, Amy A; Barocas, Victor H (2017) Planar biaxial extension of the lumbar facet capsular ligament reveals significant in-plane shear forces. J Mech Behav Biomed Mater 65:127-136
Claeson, Amy A; Barocas, Victor H (2017) Computer simulation of lumbar flexion shows shear of the facet capsular ligament. Spine J 17:109-119
Ellingson, Arin M; McGee, Corey; Nuckley, David J et al. (2017) Development, construct validity, and reproducibility of a mimetic sealed jar measuring the dynamics of opening. J Rehabil Assist Technol Eng 4:
Blixt, Nicholas C; Faulkner, Bora K; Astleford, Kristina et al. (2017) Class II and IV HDACs function as inhibitors of osteoclast differentiation. PLoS One 12:e0185441

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