This is a renewal application of grant T32 AR050958 to continue to support basic and translational research training in Inflammatory and Fibrosing Diseases centered in the Rheumatology Division at the Medical University of South Carolina (MUSC). The ultimate goal of this grant is to improve the care of rheumatic disease patients from the Southeastern United States, emphasizing research and care of African Americans with rheumatic diseases. Our training program emphasizes the interrelationship between inflammation and fibrosis and the impact of these biologic processes on end organ function such as renal disease in lupus and lung disease in scleroderma. The participating faculty have particular strength and existing collaborations in the areas of health outcomes, epidemiology of rheumatic diseases, predictors of atherosclerosis, lupus nephritis, signaling pathways leading to fibrosis, matrix proteins, scleroderma lung disease, sphingolipids, proteomics and eicosanoids. Trainees have the option of. matriculating to one of three research tracks: the bench research track for clinicians, the bench/clinical research track for non-clinicians, and the clinical investigator track which has two components, those pursuing a Master of Science in Clinical Research degree, and a non-degree clinical investigator track. The training program is structured to provide trainees with opportunities to achieve the skills that will be critical for sustained careers in academic medicine. The success of our training program, just nearing the 4""""""""^ year of its first cycle, is documented in the Progress Report. In the past 3/4 years of funding, we have supported the training of five postdoctoral fellows: two African American males and three females. Three were MD fellows, one a PhD epidemiologist, and one a translational research PhD. Four of the five remain in academic positions. The trainees were very productive with 15 manuscripts published or in press during the time period of this award, and more than 25 presentations at various local, national, and international meetings. We have three outstanding researchers on the grant this year with a number of qualified applicants for the coming years. The present application is a request for continuation of three fellowship slots.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Mancini, Marie
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Medical University of South Carolina
Internal Medicine/Medicine
Schools of Medicine
United States
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Elvington, M; Schepp-Berglind, J; Tomlinson, S (2015) Regulation of the alternative pathway of complement modulates injury and immunity in a chronic model of dextran sulphate sodium-induced colitis. Clin Exp Immunol 179:500-8
Lee, Rebecca; Reese, Charles; Bonner, Michael et al. (2014) Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease. Am J Physiol Lung Cell Mol Physiol 306:L736-48
Parks, John L; Taylor, Marian H; Parks, Laura P et al. (2014) Systemic sclerosis and the heart. Rheum Dis Clin North Am 40:87-102
Reese, Charles; Perry, Beth; Heywood, Jonathan et al. (2014) Caveolin-1 deficiency may predispose African Americans to systemic sclerosis-related interstitial lung disease. Arthritis Rheumatol 66:1909-19
Baker, DeAnna A; Eudaly, Jackie; Smith, Charles D et al. (2013) Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis. Rheumatol Int 33:2677-81
Arsenault, Patrick R; Pei, Fei; Lee, Rebecca et al. (2013) A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. J Biol Chem 288:33571-84
Li, Qingdi Quentin; Lee, Rebecca X; Liang, Huasheng et al. (2013) Anticancer activity of ?-Elemene and its synthetic analogs in human malignant brain tumor cells. Anticancer Res 33:65-76
Bedoya, Simone K; Wilson, Tenisha D; Collins, Erin L et al. (2013) Isolation and th17 differentiation of naïve CD4 T lymphocytes. J Vis Exp :e50765
Ghatnekar, Angela; Chrobak, Izabela; Reese, Charlie et al. (2013) Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol 182:2391-406
Li, Qingdi Quentin; Lee, Rebecca X; Liang, Huasheng et al. (2013) Enhancement of cisplatin-induced apoptosis by ?-elemene in resistant human ovarian cancer cells. Med Oncol 30:424

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