This program is designed to train radiation biologists in an integrated program of molecular, cellular, tissue, mutagenic, and carcinogenic effects of radiation. Both predoctoral and postdoctoral training will be offered. The program will be interdepartmental incorporating radiobiologic research resources in several laboratories at the Harvard School of Public Health, the Harvard Medical School, and associated hospitals. Research training will be accomplished by didactic and practical courses, by special lectures and lecture series, by research seminars, by research conferences, by journal clubs, and by laboratory research experience supervised by senior investigators. Laboratory research will typically focus on an aspect of ongoing, funded research, but provision will be made for exceptional students to follow avenues of their own innovation. The strength of the program resides in the broad experience and diversity of research pursued by a critical mass of training directors and supervisors who are pursuing research programs in the fields of radiation chemistry and biochemistry, cellular and molecular radiation biology, mutagenesis, carcinogenesis, cytogenetics and radiation oncology. ? ? Predoctoral trainees will have a science background in physics, chemistry and/or biology. They must be acceptable to the Program Director and must meet the admissions requirements of Harvard University. Postdoctoral trainees will be admitted by application to one of the training preceptors and with the approval of an executive committee consisting of the Program Director and one Preceptor from each training unit. It is expected that admission will be competitive. Four predoctoral and eight postdoctoral positions will be available. Trainees will be expected to pursue research and academic careers in the fields of radiation biology and radiological science including radiation oncology, nuclear medicine, and medical radiation physics. Primary research facilities will include: the Dept. of Genetics and Complex Diseases, Harvard School of Public Health; Dept. of Radiation Oncology, Harvard Medical School, Brigham and Women's Hospital, Beth Israel Deaconess Hospital, and Dana-Farber Cancer Institute; and the Lab. for Experimental Nuclear Medicine, Dept. of Radiology, Harvard Medical School. The program will be administered through the Harvard School of Public Health. In addition to classrooms, seminars rooms, departmental and university libraries, students will have access to specialized radiation sources and a large number of fully equipped laboratories including cell and tissue culture facilities, imaging facilities, and facilities for animal care. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009078-33
Application #
7285545
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1980-07-01
Project End
2010-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
33
Fiscal Year
2007
Total Cost
$476,268
Indirect Cost
Name
Harvard University
Department
Genetics
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Charles, Khanichi N; Li, Min-Dian; Engin, Feyza et al. (2017) Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep 21:393-402
Varendi, Kärt; Airavaara, Mikko; Anttila, Jenni et al. (2014) Short-term preoperative dietary restriction is neuroprotective in a rat focal stroke model. PLoS One 9:e93911
Hyduke, Daniel R; Laiakis, Evagelia C; Li, Heng-Hong et al. (2013) Identifying radiation exposure biomarkers from mouse blood transcriptome. Int J Bioinform Res Appl 9:365-85
Brace, Lear E; Vose, Sarah C; Vargas, Dorathy F et al. (2013) Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria. Aging Cell 12:1144-7
Milbury, Coren A; Correll, Mick; Quackenbush, John et al. (2012) COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing. Clin Chem 58:580-9
Balagurumoorthy, Pichumani; Xu, Xiang; Wang, Ketai et al. (2012) Effect of distance between decaying (125)I and DNA on Auger-electron induced double-strand break yield. Int J Radiat Biol 88:998-1008
ten Freyhaus, Henrik; Calay, Ediz S; Yalcin, Abdullah et al. (2012) Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab 16:81-9
Lee, Dong-Hyun; Goodarzi, Aaron A; Adelmant, Guillaume O et al. (2012) Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J 31:2403-15
Datta, Kamal; Hyduke, Daniel R; Suman, Shubhankar et al. (2012) Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland. Radiat Oncol 7:205
Song, Chen; Milbury, Coren A; Li, Jin et al. (2011) Rapid and sensitive detection of KRAS mutation after fast-COLD-PCR enrichment and high-resolution melting analysis. Diagn Mol Pathol 20:81-9

Showing the most recent 10 out of 141 publications