This program provides opportunities for twelve predoctoral and five postdoctoral trainees to master the intellectual and technical skills needed for research careers in areas fundamental to cancer. Trainees, especially predoctoral level individuals, enter the program from undergraduate education and without a commitment to cancer-related research careers. The training introduces them to a wide range of areas important to the cancer problem, emphasizing biochemical and biophysical and molecular biological approaches.
It aims to provide experience in designing experiments to formulate and answer research questions. This program has succeeded in producing individuals who contribute to the cancer research effort in their careers, and should continue to do so in the future. The training program takes advantage of the extensive resources in the biomedical sciences available within the Hopkins Medical Institutions, including the Hopkins Oncology Center. The training faculty prosecute research and provide training in the structural chemistry and function of nucleic acids, in bioorganic chemistry and enzyme reaction mechanisms; damage to DNA by carcinogens and environmental agents; the relationship of DNA repair to cancer; regulation of gene expression by antisense reagents; cellular processes involved in the synthesis, replication, transcription, repair, and recombination of DNA; biosynthesis of glycoproteins; control and regulation of gene expression; and signal transduction circuits and their control.
| Cairns, Leah; Tran, Thao; Fowl, Brendan H et al. (2018) Salvador has an extended SARAH domain that mediates binding to Hippo kinase. J Biol Chem 293:5532-5543 |
| McPherson, Robert Lyle; Ong, Shao-En; Leung, Anthony K L (2018) Quantitative Determination of MAR Hydrolase Residue Specificity In Vitro by Tandem Mass Spectrometry. Methods Mol Biol 1813:271-283 |
| Abraham, Rachy; Hauer, Debra; McPherson, Robert Lyle et al. (2018) ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proc Natl Acad Sci U S A 115:E10457-E10466 |
| Jacob, Justin T; Coulombe, Pierre A; Kwan, Raymond et al. (2018) Types I and II Keratin Intermediate Filaments. Cold Spring Harb Perspect Biol 10: |
| Armstrong, Alissa R; Drummond-Barbosa, Daniela (2018) Insulin signaling acts in adult adipocytes via GSK-3? and independently of FOXO to control Drosophila female germline stem cell numbers. Dev Biol 440:31-39 |
| Leung, Anthony K L; McPherson, Robert Lyle; Griffin, Diane E (2018) Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases. PLoS Pathog 14:e1006864 |
| Lee, Christine C; Li, Bing; Yu, Hongtao et al. (2018) Sumoylation promotes optimal APC/C Activation and Timely Anaphase. Elife 7: |
| Zhang, Tao; Wu, Yen-Ching; Mullane, Patrick et al. (2018) FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell 69:787-801.e8 |
| Abraham, Rachy; McPherson, Robert Lyle; Sreekumar, Easwaran et al. (2018) Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation. Methods Mol Biol 1813:297-316 |
| Zieman, Abigail; Coulombe, Pierre A (2018) The keratin 16 null phenotype is modestly impacted by genetic strain background in mice. Exp Dermatol 27:672-674 |
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