Abstract

The training faculty are from the Departments of Biochemistry, Environmental Health Sciences, and Reproduction Biology of John Hopkins School of Hygiene and Public Health; and from the Department of Oncology of the John Hopkins School of Medicine. The Academic and administrative base for the training program is the Department of Biochemistry. The research training in the areas of chemistry and function of nucleic acids; damage to DNA by carcinogens and environmental agents; relationship of DNA repair to cancer, replication and recombination of cellular organelles and their remodeling; control of gene expression; signal transduction circuits and their control elements. Apoptosis and cell death, and epigenetic changes to the genome and gene silencing, represent emerging research themes. These areas combine to provide the educational foundation for modern investigators in the cancer fold.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009110-25
Application #
6172514
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1975-06-30
Project End
2004-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
25
Fiscal Year
2000
Total Cost
$459,740
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Biochemistry
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Abraham, Rachy; McPherson, Robert Lyle; Sreekumar, Easwaran et al. (2018) Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation. Methods Mol Biol 1813:297-316
Zieman, Abigail; Coulombe, Pierre A (2018) The keratin 16 null phenotype is modestly impacted by genetic strain background in mice. Exp Dermatol 27:672-674
Broxton, Chynna N; He, Bixi; Bruno, Vincent M et al. (2018) A role for Candida albicans superoxide dismutase enzymes in glucose signaling. Biochem Biophys Res Commun 495:814-820
Lee, Christine C; Li, Bing; Yu, Hongtao et al. (2018) A Method for SUMO Modification of Proteins in vitro. Bio Protoc 8:
Weaver, Lesley N; Drummond-Barbosa, Daniela (2018) Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females. Genetics 209:1155-1166
Vermillion, Meghan S; Ursin, Rebecca L; Attreed, Sarah E et al. (2018) Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza. Endocrinology 159:3306-3320
Vermillion, Meghan S; Ursin, Rebecca L; Kuok, Denise I T et al. (2018) Production of amphiregulin and recovery from influenza is greater in males than females. Biol Sex Differ 9:24
Kerns, Michelle L; Hakim, Jill M C; Zieman, Abigail et al. (2018) Sexual Dimorphism in Response to an NRF2 Inducer in a Model for Pachyonychia Congenita. J Invest Dermatol 138:1094-1100
Zheng, Yi; Lei, Qijing; Jongejan, Aldo et al. (2018) The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair (Amst) 70:55-66
Hwang, Grace H; Hopkins, Jessica L; Jordan, Philip W (2018) Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II. J Vis Exp :

Showing the most recent 10 out of 166 publications