The objective of the Training Program in Immunology at Sloan-Kettering Institute is to provide postdoctoral fellows a solid foundation in the field of Immunology and to direct their interests towards important aspects of the immune system and its response to infectious agents, self-antigens, and cancer. Four postdoctoral positions are requested for this competitive renewal, which is unchanged from the past grant period. Duration of training will be two years. The Training Program provides Trainees with the intensive training, resources, and experience necessary for them to develop successful careers in academia, government, and industry as independent researchers and leaders. Areas of research training cover lymphocyte development and biology, signaling, innate immunity, infectious immunity, transplantation immunity and cancer immunology. The objectives of the Training Program are achieved by providing a structured environment with i n tensive involvement in immunology research, further strengthened by attendance at weekly seminars and research-in-progress meetings and a yearly retreat, along with participation in advanced courses covering contemporary topics of immunology. The major part of the training comes from the research experience under the tutelage of preceptors who are engaged in excellent immunology research, with bearing on lymphocyte biology, cell signaling and transcription, innate immunity, infectious diseases, autoimmune diseases, transplantation and cancer. Trainees can also take advantage of the many interdisciplinary collaborations between members of the Immunology Training Program and respected outside scientists, both locally and nationally.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009149-26
Application #
6411172
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1976-07-01
Project End
2007-02-28
Budget Start
2002-03-01
Budget End
2003-02-28
Support Year
26
Fiscal Year
2002
Total Cost
$173,052
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Wipperman, Matthew F; Heaton, Brook E; Nautiyal, Astha et al. (2018) Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. Mol Cell 72:152-161.e7
Lau, Colleen M; Sun, Joseph C (2018) The widening spectrum of immunological memory. Curr Opin Immunol 54:42-49
Lau, Colleen M; Adams, Nicholas M; Geary, Clair D et al. (2018) Epigenetic control of innate and adaptive immune memory. Nat Immunol 19:963-972
Madera, Sharline; Geary, Clair D; Lau, Colleen M et al. (2018) Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. J Immunol 200:1977-1981
Adams, Nicholas M; Lau, Colleen M; Fan, Xiying et al. (2018) Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity 48:1172-1182.e6
Geary, Clair D; Krishna, Chirag; Lau, Colleen M et al. (2018) Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection. Cell Rep 24:1949-1957.e6
Yewdell, William T; Chaudhuri, Jayanta (2017) Molecular biology: RNA editing packs a one-two punch. Nature 542:420-421
Yen, Wei-Feng; Chaudhry, Ashutosh; Vaidyanathan, Bharat et al. (2017) BRCT-domain protein BRIT1 influences class switch recombination. Proc Natl Acad Sci U S A :
Drané, Pascal; Brault, Marie-Eve; Cui, Gaofeng et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543:211-216
Budhu, Sadna; Schaer, David A; Li, Yongbiao et al. (2017) Blockade of surface-bound TGF-? on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment. Sci Signal 10:

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