Originally awarded in 1976, this application requests a five-year renewal of the T32 Training Program in Immunology at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (MSK). The objective of this Training Program is to provide junior postdoctoral fellows a solid foundation in the field of Immunology and to direct their interests towards important aspects of the immune system and its response to infectious agents, self antigens, and cancer. Three postdoctoral positions are requested for this competitive renewal. The duration of training for each trainee will be up to three years. The Training Program provides trainees with the intensive training, resources and experience necessary for them to develop successful careers in academia, government, and industry as independent researchers, mentors, and leaders. Areas of research training include tumor immunity and immune-oncology, bone marrow transplantation, lymphocyte and myeloid cell differentiation and biology, cell signaling, microbiota-host interactions, innate immunity, infectious immunity with a focus on cancer patients related infections. The objective of the Training Program is achieved by providing a structured environment with intensive involvement in immunology research, further strengthened by attendance at weekly seminars and research-in-progress meetings, monthly research colloquia and translational research seminars and an annual retreat. Trainees are also expected to participate in advanced courses covering contemporary topics of immunology and workshops on bioinformatics and grant writing skills. The major part of the training comes from the research experience under the tutelage of preceptors who are engaged in cutting-edge immunology research, with bearing on cancer and tumor immunity and related aspects of immune cell development and function at molecular, cellular and organismal levels. Trainees will be also taking advantage of the extensive interdisciplinary collaborations between members of the Immunology Training Program and respected outside scientists, both locally and nationally.
Among the major health problems afflicting the US populace today cancer and related diseases have become particularly prevalent. The Immunology Taining Program we propose will train a new cohort of postdoctoral scientists in immunology, with an emphasis on learning how the immune system interacts with tumor cells and how to mobilize the immune system to attack tumors. There have been recent remarkable successes in clinical trials in modulating the immune system to effectively treat cancer in humans, and our goal is to train new scientists to continue and expand this approach to cancer therapy.
|Wipperman, Matthew F; Heaton, Brook E; Nautiyal, Astha et al. (2018) Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease. Mol Cell 72:152-161.e7|
|Lau, Colleen M; Sun, Joseph C (2018) The widening spectrum of immunological memory. Curr Opin Immunol 54:42-49|
|Lau, Colleen M; Adams, Nicholas M; Geary, Clair D et al. (2018) Epigenetic control of innate and adaptive immune memory. Nat Immunol 19:963-972|
|Madera, Sharline; Geary, Clair D; Lau, Colleen M et al. (2018) Cutting Edge: Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. J Immunol 200:1977-1981|
|Adams, Nicholas M; Lau, Colleen M; Fan, Xiying et al. (2018) Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response. Immunity 48:1172-1182.e6|
|Geary, Clair D; Krishna, Chirag; Lau, Colleen M et al. (2018) Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection. Cell Rep 24:1949-1957.e6|
|Rapp, Moritz; Lau, Colleen M; Adams, Nicholas M et al. (2017) Core-binding factor ? and Runx transcription factors promote adaptive natural killer cell responses. Sci Immunol 2:|
|Yewdell, William T; Chaudhuri, Jayanta (2017) Molecular biology: RNA editing packs a one-two punch. Nature 542:420-421|
|Yen, Wei-Feng; Chaudhry, Ashutosh; Vaidyanathan, Bharat et al. (2017) BRCT-domain protein BRIT1 influences class switch recombination. Proc Natl Acad Sci U S A :|
|Drané, Pascal; Brault, Marie-Eve; Cui, Gaofeng et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543:211-216|
Showing the most recent 10 out of 47 publications