The focus of this training program will continue to be the training of individuals in the study of the carcinogenic consequences of environmental challenge. The field of cancer biology has expanded so rapidly that the successful training of pre-doctoral and post-doctoral students requires a multi-disciplinary educational program conducted by distinguished members of the research community. The central theme of the program will be carcinogenesis and mutagenesis. Doctoral students will take core courses in molecular biology, cell biology, genetics and cancer biology. Both pre- and post-doctoral trainees will participate in the seminar series and journal club sponsored by the program. Trainees will participate in the research activities of one of the participating faculty. The program faculty are highly interactive and have productive research programs in recombination and repair, cell cycle control, signal transduction, gene therapy, cytogenetics, radiation biology, virology and oxygen chemistry. Two post-doctoral trainees and two pre-doctoral trainees will participate in the program. Post-doctoral trainees will be selected from applicants to the individual faculty. Pre-doctoral trainees will be selected from the pool of applications to the individual departments with particular attention to those students with interests relevant to the program. The selection of trainees will be made on a competitive basis by the faculty of the program. The facilities of the faculty members are located in either (a) research laboratories of Billings Hospital, (b) Cummings Life Science Center (c) Kovler Viral Oncology Laboratory. All facilities are interconnected by tunnel to each other and the John Cerar Library.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Cancer Research Manpower and Education Review Committee (CRME)
Program Officer
Gorelic, Lester S
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University of Chicago
Schools of Medicine
United States
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Nagasubramanian, Ramamoorthy; Hansen, Ryan J; Delaney, Shannon M et al. (2008) Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure. Mutagenesis 23:341-6
Hansen, Ryan J; Nagasubramanian, Ramamoorthy; Delaney, Shannon M et al. (2007) Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis 28:1111-6
Hansen, Ryan J; Nagasubramanian, Ramamoorthy; Delaney, Shannon M et al. (2005) Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities. J Pharmacol Exp Ther 315:1247-55
Tevzadze, G G; Swift, H; Esposito, R E (2000) Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae. Chromosoma 109:72-85
Strissel, P L; Strick, R; Rowley, J D et al. (1998) An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region. Blood 92:3793-803
Super, H G; Strissel, P L; Sobulo, O M et al. (1997) Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia. Genes Chromosomes Cancer 20:185-95
Seung, L P; Mauceri, H J; Beckett, M A et al. (1995) Genetic radiotherapy overcomes tumor resistance to cytotoxic agents. Cancer Res 55:5561-5
Nucifora, G; Rowley, J D (1994) The AML1 and ETO genes in acute myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353-62
Burnett, R C; Thirman, M J; Rowley, J D et al. (1994) Molecular analysis of the T-cell acute lymphoblastic leukemia-associated t(1;7)(p34;q34) that fuses LCK and TCRB. Blood 84:1232-6
Nucifora, G; Birn, D J; Erickson, P et al. (1993) Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia. Blood 81:883-8

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