Abstract

This proposal is to continue the support of training in cancer research at Columbia University College of Physicians and Surgeons. Funds are requested to continue the support of 8 predoctoral trainees per year and to expand the program to include 4 postdoctoral trainees.
The aim of the program is to provide to individuals state-of-the-art training in the most relevant areas of modern cancer research including molecular genetics, cell biology, virology, immunology, molecular pathology, and experimental therapeutics. The participating faculty has been selected for the direct relevance of their research to the study of various aspects of the cancer problem. Trainees are chosen competitively on the basis of excellence and relevance of their project to cancer research. Trainees are required to take formal course work and seminars to provide an extensive exposure to the current state of cancer research and its future directions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009503-19
Application #
6772383
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1984-09-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
19
Fiscal Year
2004
Total Cost
$462,549
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Smith, Michael J; Bryant, Eric E; Rothstein, Rodney (2018) Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint. Genes Dev 32:1242-1251
Lee, Andreia; CingÖz, Oya; Sabo, Yosef et al. (2018) Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus. Virology 516:165-175
Frattini, Véronique; Pagnotta, Stefano M; Tala et al. (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature 553:222-227
Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad et al. (2018) Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia. Cancer Cell 34:136-147.e6
Metzger, Michael J; Paynter, Ashley N; Siddall, Mark E et al. (2018) Horizontal transfer of retrotransposons between bivalves and other aquatic species of multiple phyla. Proc Natl Acad Sci U S A 115:E4227-E4235
Li, Dawei; Tavana, Omid; Sun, Shao-Cong et al. (2018) Peli1 Modulates the Subcellular Localization and Activity of Mdmx. Cancer Res 78:2897-2910
Šušti?, Ton?i; van Wageningen, Sake; Bosdriesz, Evert et al. (2018) A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers. Genome Med 10:90
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Billon, Pierre; Bryant, Eric E; Joseph, Sarah A et al. (2017) CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons. Mol Cell 67:1068-1079.e4
Taglialatela, Angelo; Alvarez, Silvia; Leuzzi, Giuseppe et al. (2017) Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell 68:414-430.e8

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