The continuing goal of this training grant for seven predoctoral and two postdoctoral fellows in Tumor Immunology and Cancer Cell/Molecular Biology is to educate and train scientists for research and education in academia, government and industry. The training grant program is housed in the Department of Microbiology and Immunology but also includes faculty from the Departments of Biochemistry, Medicine, Pathology, Pharmacology and Radiation Medicine. The program of study is based on a new Integrated Biomedical Sciences Curriculum which provides a strong didactic base in Biochemistry, Cell Biology and Signaling, Genetics, and Molecular Biology during the first year along with the availability of exciting well-funded research programs administered by faculty with experience in training both predoctoral and postdoctoral fellows. A major strength of this program is the strong interactive training environment which exists with regard to both teaching and research. This has resulted in a high degree of collaborative research among the program faculty and trainees and with scientists outside the institution. Research training in which the 24 participating faculty are currently involved encompasses the areas of tumor immunology, oncogenes, tumor stem cells, gene regulation, molecular immunology and tumor metastasis. The program emphasizes multidisciplinary research training based on a foundation of formal instruction supported by guest and student seminar programs, journal clubs, laboratory research meetings, minisymposia, and attendance at regional and national meetings. The Cancer Center has recently recruited a new Cancer Center Director, Dr. Alfred Cohen from Memorial Sloan-Kettering Institute who has been given a substantial commitment to expand the faculty in cancer research which should benefit future training opportunities. In summary, this has been a successful program that has emphasized multidisciplinary training and has since 1985 trained 35 predoctoral and 16 postdoctoral fellows whose careers have developed in an exemplary manner.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
Schools of Medicine
United States
Zip Code
Butler, James E; Moore, Mikel B; Presnell, Steven R et al. (2009) Proteasome regulation of ULBP1 transcription. J Immunol 182:6600-9
Calfee-Mason, Karen G; Lee, Eun Y; Spear, Brett T et al. (2008) Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate. Food Chem Toxicol 46:2062-73
Schneeman, Tracey A; Bruno, Maria E C; Schjerven, Hilde et al. (2005) Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol 175:376-84
Bryson, J Scott; Zhang, Lining; Goes, Sarah W et al. (2004) CD4+ T cells mediate murine syngeneic graft-versus-host disease-associated colitis. J Immunol 172:679-87
Calfee-Mason, Karen G; Spear, Brett T; Glauert, Howard P (2004) Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate. Toxicol Appl Pharmacol 199:1-9
Fernandez, Stefan; Knopf, Melissa A; Shankar, Gopi et al. (2003) Calcitonin gene-related peptide indirectly inhibits IL-7 responses in pre-B cells by induction of IL-6 and TNF-alpha in bone marrow. Cell Immunol 226:67-77
Flanagan, D M; Jennings, C D; Goes, S W et al. (2002) Nitric oxide participates in the intestinal pathology associated with murine syngeneic graft-versus-host disease. J Leukoc Biol 72:762-8
Calfee-Mason, Karen G; Spear, Brett T; Glauert, Howard P (2002) Vitamin E inhibits hepatic NF-kappaB activation in rats administered the hepatic tumor promoter, phenobarbital. J Nutr 132:3178-85
Hempen, Paula M; Phillips, Kimberly M; Conway, Pamela S et al. (2002) Transcriptional regulation of the human polymeric Ig receptor gene: analysis of basal promoter elements. J Immunol 169:1912-21
McGillis, Joseph P; Miller, Christopher N; Schneider, David B et al. (2002) Calcitonin gene-related peptide induces AP-1 activity by a PKA and c-fos-dependent mechanism in pre-B cells. J Neuroimmunol 123:83-90

Showing the most recent 10 out of 36 publications