): The Karmanos Cancer Institute (KCI), which is the new designation of the Michigan Cancer Foundation, the operating body of the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit, supports through administrative, resource and developmental funds a variety of research programs. These investigations are carried out by established investigators on the liberal arts campus of Wayne State University, the School of Medicine and at the KCI Prentis Building. As a result there exists extensive expertise and productivity in a number of areas of basic cancer research; namely breast c a ncer, carcinogenesis, tumor progression and metastasis, experimental therapeutics, drug discovery and molecular genetics. The amount and quality of cancer research being pursued in the KCI has made this a highly desirable environment for the training of laboratory investigators. By combining the cancer research efforts of 11 senior faculty of the Institute, it continues to be possible to offer a superior and technologically up-to-date experience to predoctoral students in the investigative areas described above. In addition, the collaboration of the training faculty in this Institute has resulted in a synergism which initiated and sustains a Graduate Program in Cancer Biology within Wayne State University. Thus, extended cancer courses, lectures, seminars and symposia heighten the training which culminates in a Ph.D. in Cancer Biology. In its eleventh year, this training grant will focus on the training of five predoctoral students in the Graduate Program in Cancer Biology. The training of selected students from this interdisciplinary graduate program will be augmented by a two to three year appointment to this NCI sponsored training grant. These students will receive intensive instruction that will enable each to pursue a successful career in cancer research. The KCI has always concentrated on the recruiting and training of minorities. Graduate students will have the opportunity to become familiar with the latest techniques of molecular biology, genetics, tissue culture, cellular transfection, flow cytometry, drug screening, x-ray crystallography, NMR, EPR, GC/MS 2D PAGE, confocal imaging and image analysis. In addition, students will have the opportunity to integrate their basic research experiences with clinical oncology problems via attendance at the Cancer Center Lecture Series and Oncology Grand Rounds. Trainees will thus gain an understanding of, and appreciation for, translational research in oncology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009531-15
Application #
6349994
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1985-09-01
Project End
2002-08-31
Budget Start
2001-02-08
Budget End
2002-08-31
Support Year
15
Fiscal Year
2001
Total Cost
$122,444
Indirect Cost
Name
Wayne State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
McFall, Thomas; McKnight, Brooke; Rosati, Rayna et al. (2018) Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen. J Biol Chem 293:1163-1177
Shah, Seema; Brock, Ethan J; Jackson, Ryan M et al. (2018) Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation. Neoplasia 20:951-963
Jones, Steven K; Douglas, Kirk; Shields, Anthony F et al. (2018) Correlating quantitative tumor accumulation and gene knockdown using SPECT/CT and bioluminescence imaging within an orthotopic ovarian cancer model. Biomaterials 178:183-192
Guastella, Anthony R; Michelhaugh, Sharon K; Klinger, Neil V et al. (2018) Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. J Neurooncol 139:239-249
Saadat, Nadia; Liu, Fangchao; Haynes, Brittany et al. (2018) Nano-delivery of RAD6/Translesion Synthesis Inhibitor SMI#9 for Triple-negative Breast Cancer Therapy. Mol Cancer Ther 17:2586-2597
Heyza, Joshua; Lei, Wen; Watza, Donovan et al. (2018) Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer. Clin Cancer Res :
Ravindra, Manasa; Wilson, Mike R; Tong, Nian et al. (2018) Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 61:4228-4248
McKnight, Brooke N; Viola-Villegas, Nerissa T (2018) 89 Zr-ImmunoPET companion diagnostics and their impact in clinical drug development. J Labelled Comp Radiopharm 61:727-738
Herroon, Mackenzie K; Rajagurubandara, Erandi; Diedrich, Jonathan D et al. (2018) Adipocyte-activated oxidative and ER stress pathways promote tumor survival in bone via upregulation of Heme Oxygenase 1 and Survivin. Sci Rep 8:40
Blocker, Stephanie J; Shields, Anthony F (2018) Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery. Mol Imaging Biol 20:340-351

Showing the most recent 10 out of 164 publications