): The program proposes to provide research training in oncological imaging for postdoctoral fellows interested in a career in academic radiology and related fields. The program structure includes didactic and laboratory exposure and provides basic scientists and physicians with opportunity to gain research training in state-of- the-art medical imaging facilities. The unique aspect of this training program is that it combines training within an imaging core with training in either a basic science, such as molecular oncology or cancer biology, or in an imaging modality, such as CT or MR. The exposure of both clinical and basic science research is strong feature of this program. The M.D. and Ph.D. trainees who complete this program will be uniquely qualified for a variety of positions in academic radiology oriented towards research in clinical oncology and oncological imaging. This program addresses the pressing need to encourage physicians and researchers in radiology to develop and maintain a research focus and to keep pace with the rapid influx of imaging and diagnostic methods which require an increasing amount of technical expertise. Areas of research expertise include: functional (MRI, MRS and PET) imaging of human and animal tumors, intraarterial delivery of drugs active in the treatment of brain tumors, development of inhibitors of tumor angiogene-sis, applications of bioerodible, sustained-release polymers, monitoring of the proliferative state and therapeutic response of brain tumors, biochemical and clinical pharmacology studies of anti-tumor agents, computer modeling of interactions of alkylating agents with deoxynucleotides and polynucleotides, in vivo NMR spectroscopy as a noninvasive monitor of the biochemistry and physiology of malignant tumors, image guided navigation of surgical instruments for tumor surgery and image processing of CT and MRI data for tumor 3-D reconstruction, interactive 2-D and 3-D imaging, automated volumetrics, and radiation therapy planning. The multi-disciplinary training program described in this proposal draws its strength from the participation of faculty members from numerous departments, including radiology, oncology, medicine, neurosurgery, biomedical engineering, urology and pathology. Extensive research facilities available to trainees not only reflect the wide variety of disciplines contributing to the program but also the commitment of the Johns Hopkins Medical Institutions to training future leaders of biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009630-13
Application #
6375547
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1989-08-01
Project End
2003-09-29
Budget Start
2001-09-30
Budget End
2003-09-29
Support Year
13
Fiscal Year
2001
Total Cost
$99,071
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jacobs, Michael A; Herskovits, Edward H; Kim, Hyun S (2005) Uterine fibroids: diffusion-weighted MR imaging for monitoring therapy with focused ultrasound surgery--preliminary study. Radiology 236:196-203
Restrepo, Lucas; Jacobs, Michael A; Barker, Peter B et al. (2005) Etiology of perfusion-diffusion magnetic resonance imaging mismatch patterns. J Neuroimaging 15:254-60
Restrepo, Lucas; Jacobs, Michael A; Barker, Peter B et al. (2004) Assessment of transient ischemic attack with diffusion- and perfusion-weighted imaging. AJNR Am J Neuroradiol 25:1645-52
Jacobs, Michael A; Barker, Peter B; Bottomley, Paul A et al. (2004) Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study. J Magn Reson Imaging 19:68-75
Jacobs, Michael A; Barker, Peter B; Bluemke, David A et al. (2003) Benign and malignant breast lesions: diagnosis with multiparametric MR imaging. Radiology 229:225-32
Hillis, A E; Wityk, R J; Tuffiash, E et al. (2001) Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke. Ann Neurol 50:561-6
Jacobs, M A; Horska, A; van Zijl, P C et al. (2001) Quantitative proton MR spectroscopic imaging of normal human cerebellum and brain stem. Magn Reson Med 46:699-705
Ferguson, A T; Evron, E; Umbricht, C B et al. (2000) High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci U S A 97:6049-54
Raman, V; Tamori, A; Vali, M et al. (2000) HOXA5 regulates expression of the progesterone receptor. J Biol Chem 275:26551-5
Nacht, M; Ferguson, A T; Zhang, W et al. (1999) Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res 59:5464-70

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