Over the last several years, the pool of physician-scientists in Health Sciences and their participation in training grants has decreased. The major objective of this training grant in Basic Research in Oncology, funded by the NCI for the last 10 years, is to train young individuals at the post-doctoral level who are motivated in the pursuit of an academic career that involves research in the area of malignant diseases in humans. The focus is in particular on the training of future physician-scientists, who are judged essential in the successful translation of basic discoveries from the laboratory to the clinic. Despite a shortage of suitable candidates, 7 among 8 individuals who completed the program over the last 10 years and hold academic positions are physicians. The proposed program involves 27 senior investigators on the faculty of the Keck School of Medicine at the University of Southern California who are members of the NCI funded Norris Comprehensive Cancer Center. Their research interests are in the areas of Cancer Genetics, Regulatory Biology, Developmental Therapeutics/Clinical Trials, Cancer Epidemiology/Control and Hematological Malignancies. The research of these faculty members is supported by $26.2 million in NIH funding and all members have a solid experience in training young investigators. For the next 5 years, we anticipate being able to support 3 candidates each year. Recruitment for this training grant will continue to be primarily from 2 subspecialty fellowship programs, in Pediatric Hematology-Oncology at Children's Hospital Los Angeles (CHLA) and in Medical Hematology-Oncology at the Health Sciences Campus (HSC) of USC. Over the last 2 years these programs have been able to recruit an increased number of well qualified applicants. The training grant will also extend to other post-doctoral programs at USC and other medical schools. Participants in the training grant will have access to a broad spectrum of educational activities organized at CHLA, and at the HSC campuses, including a required curriculum focused on cancer biology, biostatistics, bioinformatics, and experimentation. Their training will continue to be closely monitored by an advisory committee. Support for this training grant is critical in allowing us to continue to promote physician-scientist careers in pediatric and medical oncology.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital of Los Angeles
Los Angeles
United States
Zip Code
Bl├╝ml, Stefan; Margol, Ashley S; Sposto, Richard et al. (2016) Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol 18:126-31
Margol, Ashley S; Robison, Nathan J; Gnanachandran, Janahan et al. (2015) Tumor-associated macrophages in SHH subgroup of medulloblastomas. Clin Cancer Res 21:1457-65
HaDuong, Josephine H; Blavier, Laurence; Baniwal, Sanjeev K et al. (2015) Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer 137:797-809
Anderson, Clarke P; Matthay, Katherine K; Perentesis, John P et al. (2015) Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma. Pediatr Blood Cancer 62:1739-46
Cooper, Aaron; van Doorninck, John; Ji, Lingyun et al. (2011) Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group. Clin Cancer Res 17:56-66
Gruber, Tanja Andrea; Chang, Mi Sook; Sposto, Richard et al. (2010) Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia. Cancer Res 70:7411-20
van Doorninck, John A; Ji, Lingyun; Schaub, Betty et al. (2010) Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol 28:1989-94
Li, Angela Y J; Boo, Lee Ming; Wang, Shih-Ya et al. (2009) Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res 69:5699-706
Jariwala, Unnati; Cogan, Jon P; Jia, Li et al. (2009) Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. Prostate 69:392-400
Trageser, Daniel; Iacobucci, Ilaria; Nahar, Rahul et al. (2009) Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med 206:1739-53

Showing the most recent 10 out of 35 publications