The overall objective of the program is to train clinicians in the area of head and neck oncology for a career in basic science research. This unique Research Training Program enables trainees to develop both basic research and clinical skills. Potential trainees are selected from the outstanding pool of candidates that apply to the Residency Program in Otolaryngology. Trainees can choose preceptors with research interests that span a variety of disciplines, including pharmacology, molecular biology, immunology, experimental therapeutics and human genetics. Trainees evaluate and choose a preceptor during the first year of Residency (General Surgery). During years 2 and 3, trainees spend protected time in their preceptor's laboratory in basic science research efforts developing their project area. In these 2 uninterrupted research years, pertinent course work and seminar programs, journal clubs are also required. Years 4-6 involve continuation of their rotation through clinical activities in the Otolaryngology Residency Program with an additional 3 months/years in years 4 and 5 allotted to their laboratory research projects. The trainee's progress as well as the preceptor's activities and the overall program is monitored and evaluated by an Administrative Committee. One to two new trainees are admitted to our program per year and trainees with either an M.D. or M.D./Ph.D. are considered. The research activities of the trainees remain under the tutelage of the preceptors throughout their research program. Trainees are encouraged to develop their own independent research program. Trainees are encouraged to develop their own independent research areas upon completion of their training, and will be capable of establishing themselves in an academic environment not only as a clinical researcher, but also as a basic scientist.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Gorelic, Lester S
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University of Pittsburgh
Schools of Medicine
United States
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Lu, Shanhong; Concha-Benavente, Fernando; Shayan, Gulidanna et al. (2018) STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer. Oral Oncol 78:186-193
Gleber-Netto, Frederico O; Zhao, Mei; Trivedi, Sanchit et al. (2018) Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma. Cancer 124:84-94
Liu, Zhuqing; McMichael, Elizabeth L; Shayan, Gulidanna et al. (2018) Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients. Clin Cancer Res 24:4529-4538
Shayan, Gulidanna; Srivastava, Raghvendra; Li, Jing et al. (2017) Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer. Oncoimmunology 6:e1261779
Srivastava, Raghvendra M; Trivedi, Sumita; Concha-Benavente, Fernando et al. (2017) CD137 Stimulation Enhances Cetuximab-Induced Natural Killer: Dendritic Cell Priming of Antitumor T-Cell Immunity in Patients with Head and Neck Cancer. Clin Cancer Res 23:707-716
Kansy, Benjamin A; Concha-Benavente, Fernando; Srivastava, Raghvendra M et al. (2017) PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. Cancer Res 77:6353-6364
Panebianco, Federica; Kelly, Lindsey M; Liu, Pengyuan et al. (2017) THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer. Proc Natl Acad Sci U S A 114:2307-2312
Albergotti, William G; Gooding, William E; Kubik, Mark W et al. (2017) Assessment of Surgical Learning Curves in Transoral Robotic Surgery for Squamous Cell Carcinoma of the Oropharynx. JAMA Otolaryngol Head Neck Surg 143:542-548
Huyett, Phillip; Gilbert, Mark; Liu, Lijun et al. (2017) A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma. J Vis Exp :
Moy, Jennifer D; Moskovitz, Jessica M; Ferris, Robert L (2017) Biological mechanisms of immune escape and implications for immunotherapy in head and neck squamous cell carcinoma. Eur J Cancer 76:152-166

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