Over one million Americans will suffer from cancer every year, and approximately half of them will die from the disease. Despite major efforts to prevent cancer, effective early diagnosis and treatment of non- metastatic disease remains the hallmark of modern effective cancer management. Surgery persists as a major diagnostic and therapeutic modality for the management of cancer and advances in the technology of surgical technique (such as fiber-optic and radio-nucleotide visualization of normal and diseased tissue and miniaturization and robotic control of instruments) have contributed to the improved care of the cancer patient. Nonetheless, it is an understanding of the biologic basis of the disease and the effective diagnostic and therapeutic management of cancer within a multidisciplinary context that will bring the greatest advances over the next decade. In the current era of discovery, the opportunities for the education and training of surgeons in the biologic basis of cancer are unprecedented. The advances in cancer genetics, cell biology and immunology provide important opportunities for basic, translational and clinical studies in cancer research. This opportunity to educate and train future generations of surgical scientists and leaders provided a compelling imperative for this application for a training grant in translational studies in surgical oncology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA093245-08
Application #
7686897
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M1))
Program Officer
Myrick, Dorkina C
Project Start
2002-01-01
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
8
Fiscal Year
2009
Total Cost
$403,814
Indirect Cost
Name
Duke University
Department
Surgery
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Maley, Carlo C; Aktipis, Athena; Graham, Trevor A et al. (2017) Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer 17:605-619
Beasley, Georgia M; Speicher, Paul; Augustine, Christina K et al. (2015) A multicenter phase I dose escalation trial to evaluate safety and tolerability of intra-arterial temozolomide for patients with advanced extremity melanoma using normothermic isolated limb infusion. Ann Surg Oncol 22:287-94
Speicher, Paul J; Meriwether, Claire H; Tyler, Douglas S (2015) Regional therapies for in-transit disease. Surg Oncol Clin N Am 24:309-22
Turley, Ryan S; Tokuhisa, Yoshihiro; Toshimitsu, Hiroaki et al. (2015) Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg 261:368-77
Jiang, Betty S; Speicher, Paul J; Thomas, Samantha et al. (2015) Quality of life after isolated limb infusion for in-transit melanoma of the extremity. Ann Surg Oncol 22:1694-700
James, Michael L; Andersen, Nicholas D; Swaminathan, Madhav et al. (2014) Predictors of electrocerebral inactivity with deep hypothermia. J Thorac Cardiovasc Surg 147:1002-7
Lidsky, Michael; Antoun, Gamil; Speicher, Paul et al. (2014) Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. J Biol Chem 289:27714-26
Beasley, Georgia M; Speicher, Paul; Sharma, Ketan et al. (2014) Efficacy of repeat sentinel lymph node biopsy in patients who develop recurrent melanoma. J Am Coll Surg 218:686-92
Andersen, Nicholas D; Hanna, Jennifer M; Ganapathi, Asvin M et al. (2014) Insurance status predicts acuity of thoracic aortic operations. J Thorac Cardiovasc Surg 148:2082-6
Jiang, Betty S; Beasley, Georgia M; Speicher, Paul J et al. (2014) Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma. Ann Surg Oncol 21:2525-31

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