The objective of the Integrated Biological Systems Training in Oncology (IBSTO) program is to prepare predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. This training focuses on basic cellular processes and mechanisms that are shared between cell biology and developmental biology that are critical to understanding how cells become tumorigenic and on how to translate this basic research knowledge to the diagnosis, treatment and prevention of cancer. The IBSTO program will take place in an active and growing Medical Center environment with state-of-the-art facilities, a vibrant NCI-designated comprehensive cancer center, top ranked basic science departments, an Interdisciplinary Graduate Program in Biomedical Sciences, an active Office of Postdoctoral Affairs, and an Alliance with a neighboring minority-serving medical college. The Program Director has a strong record of basic cancer research and administrative experience. Trainees will be placed with experienced, well-funded, productive preceptors in an interactive research environment with extensive resources. The three broad areas of experience of our preceptors are in cell biology, developmental biology/genetics and medicine. Each trainee will have mentors from each group to provide unique and valuable perspectives to enhance their cancer-related research training. The goals of our training program are to provide proactive mentoring and oversight, provide cross-discipline education and research, provide training in cutting edge methodology, develop useful academic skills, foster interactions with faculty and other trainees, provide exposure to current cancer research discoveries, and provide exposure to clinical cancer treatment and translational research. We strongly believe that it is essential to integrate basic science research training in cell biology, developmental biology and genetics that allows understanding of the multiple lesions in cellular processes that define cancer, with a knowledge and appreciation of the clinical aspects of cancer. This combined understanding will be critical to our diagnosis, treatment and eventually the prevention of this disease.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
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Vanderbilt University Medical Center
Anatomy/Cell Biology
Schools of Medicine
United States
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Norris, Stephen R; Jung, Seungyeon; Singh, Prashant et al. (2018) Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters. Nat Commun 9:2659
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Lawrence, Elizabeth J; Arpag, Göker; Norris, Stephen R et al. (2018) Human CLASP2 specifically regulates microtubule catastrophe and rescue. Mol Biol Cell 29:1168-1177
Willet, Alaina H; Bohnert, K Adam; Gould, Kathleen L (2018) Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation. Mol Biol Cell 29:713-721
Elmore, Zachary C; Guillen, Rodrigo X; Gould, Kathleen L (2018) The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole. Mol Biol Cell 29:1664-1674
Jones, Christine M; Chen, Jun-Song; Johnson, Alyssa E et al. (2018) Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization. Mol Biol Cell 29:2176-2189
Choi, Eunyoung; Lantz, Tyler L; Vlacich, Gregory et al. (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67:1595-1605
Ryan, Kaitlyn E; Kim, Patrick S; Fleming, Jonathan T et al. (2017) Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex. Dev Biol 432:165-177
Sanders, Anna A W M; Chang, Kevin; Zhu, Xiaodong et al. (2017) Nonrandom ?-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi. Mol Biol Cell 28:3181-3192
Shannon, Erica K; Stevens, Aaron; Edrington, Westin et al. (2017) Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds. Biophys J 113:1623-1635

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