The objective of this first renewal of the Integrated Biological Systems Training in Oncology (IBSTO) program is to continue to prepare predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. IBSTO training focuses on basic cellular processes and mechanisms that are shared between cell biology and developmental biology that are critical to understanding how cells become tumorigenic and on how to translate this basic research knowledge to the diagnosis, treatment and prevention of cancer. The IBSTO program takes place in an active and growing Medical Center environment with state-of-the-art facilities, a vibrant NCI-designated comprehensive cancer center, top-ranked basic science departments, an Interdisciplinary Graduate Program in Biomedical Sciences, and an active Office of Postdoctoral Affairs. The Program Director has a strong record of basic cancer research and administrative experience. In our first four years we have already recruited 22 outstanding predoctoral and postdoctoral trainees that have been very productive. Trainees have been placed with experienced, well-funded, productive preceptors in an interactive research environment with extensive resources. The three broad areas of experience of our preceptors are in cell biology, developmental biology/genetics and medicine. Each trainee has mentors from each group to provide unique and valuable perspectives to enhance their cancer-related research training. The goals of our training program are to provide proactive mentoring and oversight, provide cross-discipline education and research, provide training in cutting edge methodology, develop useful academic skills, foster interactions with faculty and other trainees, provide exposure to current cancer research discoveries, and provide exposure to clinical cancer treatment and translational research. In this renewal we have strengthened our clinical/translational component with the addition of an Associate Director and new preceptors who focus on translational research and new required clinical training experience in oncology. We strongly believe that integrating basic science research training in cell biology, developmental biology and genetics with translational and clinical experience allows a better understanding of the multiple lesions in cellular processes that define cancer, which is critical t diagnosing, treating and eventually preventing of this disease.

Public Health Relevance

The Integrated Biological Systems Training in Oncology (IBSTO) program prepares predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. The IBSTO program takes place in an active Medical Center environment with state-of-the-art facilities, experienced preceptors in an interactive education and research environment with extensive resources and insitutional commitment. The IBSTO program provides our productive trainees unique mentoring, useful academic skills, interactions with faculty and other trainees, exposure to current cancer research discoveries and exposure to clinical cancer treatment and translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA119925-06
Application #
8551189
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2006-04-01
Project End
2018-06-30
Budget Start
2013-07-05
Budget End
2014-06-30
Support Year
6
Fiscal Year
2013
Total Cost
$390,165
Indirect Cost
$28,974
Name
Vanderbilt University Medical Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Choi, Eunyoung; Lantz, Tyler L; Vlacich, Gregory et al. (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67:1595-1605
Norris, Stephen R; Jung, Seungyeon; Singh, Prashant et al. (2018) Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters. Nat Commun 9:2659
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Lawrence, Elizabeth J; Arpag, Göker; Norris, Stephen R et al. (2018) Human CLASP2 specifically regulates microtubule catastrophe and rescue. Mol Biol Cell 29:1168-1177
Willet, Alaina H; Bohnert, K Adam; Gould, Kathleen L (2018) Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation. Mol Biol Cell 29:713-721
Elmore, Zachary C; Guillen, Rodrigo X; Gould, Kathleen L (2018) The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole. Mol Biol Cell 29:1664-1674
Jones, Christine M; Chen, Jun-Song; Johnson, Alyssa E et al. (2018) Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization. Mol Biol Cell 29:2176-2189
Ryan, Kaitlyn E; Kim, Patrick S; Fleming, Jonathan T et al. (2017) Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex. Dev Biol 432:165-177
Sanders, Anna A W M; Chang, Kevin; Zhu, Xiaodong et al. (2017) Nonrandom ?-TuNA-dependent spatial pattern of microtubule nucleation at the Golgi. Mol Biol Cell 28:3181-3192
Shannon, Erica K; Stevens, Aaron; Edrington, Westin et al. (2017) Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds. Biophys J 113:1623-1635

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