This application is for renewal of a training program directed by Louis Hersh and co-directed by Linda Dwoskin and Sharon Walsh. We request continued support for four predoctoral and two postdoctoral trainees utilizing a training faculty of 15 housed in three colleges and 5 different departments within the University of Kentucky. All of the training faculty have been funded through NIDA or collaborate with NIDA funding training faculty with their research broadly focused on the molecular aspects of drug abuse. The University of Kentucky has a long history of involvement in drug abuse research and includes the Center on Drug and Alcohol Research and the Center for Drug and Alcohol Research and Translation. The goal of this training program continues to be the preparation of promising graduate students and postdoctoral fellows for careers in drug abuse research. The program provides broad-based training in modern aspects of drug abuse research with a particular emphasis on studying the cellular and molecular aspects of receptors involved in the response to drugs and the development of ligands which interact with these receptors as potential pharmacotherapy's for drug abuse. The training faculty share a common interest in understanding basic mechanisms related to drug abuse at the molecular level. The emphasis of the training faculty focus on the structure of opiate receptor ligands, the effects of opiate receptor ligands on physiological processes, and the structure and function of the proteins and ligands involved in opiate receptors. Trainees learn from a strong faculty who utilize state-of-the-art methodological approaches to drug abuse research. A unique aspect of this program is the interaction of trainees with other faculty and trainees involved in the behavioral aspects of drug abuse, giving them a broad based understanding of drug abuse research. This unique training opportunity is hoped to fill the need for new investigators in drug abuse research who have a broad understanding of the field.

Public Health Relevance

This program is designed to train graduate students and postdocs for a career in drug abuse research, providing them with the tools to conduct research on the molecular aspects of drug abuse while at the same time endowing them with an understanding of the behavioral aspects of drug abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA016176-09
Application #
8286390
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2003-06-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$270,933
Indirect Cost
$17,225
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Smith, Aaron P; Hofford, Rebecca S; Zentall, Thomas R et al. (2018) The role of 'jackpot' stimuli in maladaptive decision-making: dissociable effects of D1/D2 receptor agonists and antagonists. Psychopharmacology (Berl) 235:1427-1437
Chow, Jonathan J; Beckmann, Joshua S (2018) NMDA receptor blockade specifically impedes the acquisition of incentive salience attribution. Behav Brain Res 338:40-46
Hayes, Dayna M; Nickell, Chelsea G; Chen, Kevin Y et al. (2018) Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. Neuropharmacology 133:276-288
Maggio, Sarah E; Saunders, Meredith A; Nixon, Kimberly et al. (2018) An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic ?6?2* antagonist r-bPiDI. Drug Alcohol Depend 193:154-161
Maggio, Sarah E; Saunders, Meredith A; Baxter, Thomas A et al. (2018) Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology (Berl) 235:1439-1453
Hankosky, Emily R; Westbrook, Sara R; Haake, Rachel M et al. (2018) Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes. Psychopharmacology (Berl) 235:861-871
Weiss, Virginia G; Yates, Justin R; Beckmann, Joshua S et al. (2018) Social reinstatement: a rat model of peer-induced relapse. Psychopharmacology (Berl) 235:3391-3400
Freeman, Patricia R; Hankosky, Emily R; Lofwall, Michelle R et al. (2018) The changing landscape of naloxone availability in the United States, 2011 - 2017. Drug Alcohol Depend 191:361-364
Heidary, David K; Fox, Ashley; Richards, Chris I et al. (2017) A High-Throughput Screening Assay Using a Photoconvertable Protein for Identifying Inhibitors of Transcription, Translation, or Proteasomal Degradation. SLAS Discov 22:399-407
Shrestha, Sanjib K; Kril, Liliia M; Green, Keith D et al. (2017) Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents. Bioorg Med Chem 25:58-66

Showing the most recent 10 out of 98 publications