This new institutional grant requests funds for four postdoctoral positions for training and research in neuroimaging. Two general classes of neuroimaging will be emphasized: radiotracer and nuclear magnetic resonance. The specific imaging methods are described by the following acronyms: PET (positron emission tomography, MRI (magnetic resonance imaging), fMRI (functional magnetic resonance imaging), and MRS (magnetic resonance spectroscopy). These imaging methodologies offer real promise for the expanded clinical utility of neuroimaging in the diagnosis, treatment, and understanding of the pathophysiology of major neuropsychiatric disorders. However, these new methodologies typically derive from complex, multidisciplinary sciences, which thereby create a challenging information barrier to their further development and application in medical practice. The purposes of the proposed program are the following: - Provide formal course training to postdoctoral fellows, with an emphasis on imaging and clinical research methodology, and instruction in their underlying multidisciplinary sciences. - Provide mentored training for fellows to apply these new methods to the interdisciplinary advance of our understanding of the function of the brain in health, substance abuse, and other psychiatric diseases. - Provide an integrated research experience for the fellows in both imaging applications and methodology. All fellows will be expected to complete at least one research project with an applications and one with a methodology mentor during their training period. The integration of training in methodology and imaging applications will be enhanced by the organization of this program as two interactive tracks of approximately equal size: Methodology and Application. We expect that the majority of fellows in the Methodology track will have Ph.D. degrees, and those in the Application track, primarily M.D. degrees. Each fellow will have a primary and secondary faculty mentor to represent the two tracks.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA022975-02
Application #
7458962
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Kautz, Mary A
Project Start
2007-07-01
Project End
2013-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
2
Fiscal Year
2009
Total Cost
$241,923
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Zhai, Zu Wei; Yip, Sarah W; Morie, Kristen P et al. (2018) Substance-use initiation moderates the effect of stress on white-matter microstructure in adolescents. Am J Addict 27:217-224
Thompson, Garth J; Sanganahalli, Basavaraju G; Baker, Keeley L et al. (2018) Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. Neuroimage 172:586-596
Kong, Xiang-Zhen; Mathias, Samuel R; Guadalupe, Tulio et al. (2018) Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A 115:E5154-E5163
Hsu, Wei-Ting; Rosenberg, Monica D; Scheinost, Dustin et al. (2018) Resting-state functional connectivity predicts neuroticism and extraversion in novel individuals. Soc Cogn Affect Neurosci 13:224-232
Yip, Sarah W; Worhunsky, Patrick D; Xu, Jiansong et al. (2018) Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions. Addict Biol 23:394-402
Blaine, Sara K; Nautiyal, Nisheet; Hart, Rachel et al. (2018) Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non-binge drinkers. Addict Biol :
Johnson, Frances K; Delpech, Jean-Christophe; Thompson, Garth J et al. (2018) Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry 8:49
Rosenberg, Monica D; Hsu, Wei-Ting; Scheinost, Dustin et al. (2018) Connectome-based Models Predict Separable Components of Attention in Novel Individuals. J Cogn Neurosci 30:160-173
Goldfarb, Elizabeth V; Sinha, Rajita (2018) Drug-Induced Glucocorticoids and Memory for Substance Use. Trends Neurosci 41:853-868
Bhatt, Shivani; Hillmer, Ansel T; Nabulsi, Nabeel et al. (2018) Evaluation of (-)-[18 F]Flubatine-specific binding: Implications for reference region approaches. Synapse 72:

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