Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the forward translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in backward- translation -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translational researchers, this application proposes continuation of a successful (17 total trainees; 13 in the current funding period) NIDA T32 Translational Addiction Research Fellowship at the University of Pennsylvania. The (pre- and postdoctoral) training program make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.s or M.D.s, who will accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the dual (clinical - preclinical) mentoring, and in the trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma ,stress, cultural norms) influences. Trainees are thus offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn Center for Studies on Addiction; Translational Research Laboratories/CNB; Center for AIDS Research; Center for Integrated Nicotine Research (CIRNA), the Treatment Research Institute, and collaborative laboratories offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the real world?.

Public Health Relevance

The proposed continuation of a recently-funded T32 Translational Addiction Research Fellowship at the University of Pennsylvania will give 4 pre-doctoral and 4 post-doctoral trainees the framework, and the skills, to speed the next generation of effective addiction treatments ? with concomitant benefit for the addiction-linked public health problems of violence, crime and HIV/AIDs.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Kautz, Mary A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Schools of Medicine
United States
Zip Code
Reilly, Sean W; Makvandi, Mehran; Xu, Kuiying et al. (2018) Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature. Org Lett 20:1752-1755
Guercio, Leonardo A; Hofmann, Mackenzie E; Swinford-Jackson, Sarah E et al. (2018) A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology 43:1395-1404
Shi, Zhenhao; Wang, An-Li; Jagannathan, Kanchana et al. (2018) Effects of extended-release naltrexone on the brain response to drug-related stimuli in patients with opioid use disorder. J Psychiatry Neurosci 43:170036
Jiang, Ke; Wu, Shi; Shi, Zhenhao et al. (2018) Activations of the dorsolateral prefrontal cortex and thalamus during agentic self-evaluation are negatively associated with trait self-esteem. Brain Res 1692:134-141
Hernandez, Nicole S; Ige, Kelsey Y; Mietlicki-Baase, Elizabeth G et al. (2018) Glucagon-like peptide-1 receptor activation in the ventral tegmental area attenuates cocaine seeking in rats. Neuropsychopharmacology 43:2000-2008
Swinford-Jackson, Sarah E; Pierce, R Christopher (2018) Harmony and heresy of an L-type calcium channel inhibitor: suppression of cocaine seeking via increased dopamine transmission in the nucleus accumbens. Neuropsychopharmacology 43:2335-2336
Reilly, Sean W; Puentes, Laura N; Schmitz, Alexander et al. (2018) Synthesis and evaluation of an AZD2461 [18F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. Bioorg Chem 83:242-249
An, Sieun; Han, Xiaochun; Wu, Bing et al. (2018) Neural activation in response to the two sides of emotion. Neurosci Lett 684:140-144
Manners, M T; Yohn, N L; Lahens, N F et al. (2018) Transgenerational inheritance of chronic adolescent stress: Effects of stress response and the amygdala transcriptome. Genes Brain Behav :e12493
Ramey, Tatiana; Regier, Paul S (2018) Cognitive impairment in substance use disorders. CNS Spectr :1-12

Showing the most recent 10 out of 45 publications