The purpose of this training program is to provide a stimulating environment for interdisciplinary studies leading to Ph.D. or M.S. degrees in the field of dental biomaterials. The main themes for study include: (a) the synthesis, characterization and physical phenomena related to the behavior of biomaterials in service; (b) the biological interactions between materials and living cells; and (c) experimental design of laboratory and clinical investigations. Resources for accomplishing these three goals include the Horace H. Rackham School of Graduate Studies, the Materials Science and Engineering Department and the Bioengineering Program in the School of Engineering, the Biostatistics Department in the School of Public Health, the Oral Health Sciences Program in the School of Dentistry, Clinical Research Centers in the School of Dentistry, the Biomaterials Properties Database on the Internet, and an NIDR Specialized Materials Science Research Center (SMSRC) Grant. Projects in the SMSRC include ceramics (strengthening by hydration of glasses and controlled crystallization of leucite; near net shape forming for greater accuracy; new calcium aluminate cements), composites (alignment of filler particles with electric fields, reduction of curing shrinkage with microballoons, synthesis of liquid crystalline (LC)/silsesquixoxane copolymers), and biocompatibility (assessments of new restorative materials). The training faculty have an important diversity of backgrounds having Ph.D. degrees in (1) dental biomaterials (Dr. O'Brien), (2) analytical chemistry (Dr. Morris), (3) metallurgy (Dr. O'Brien), (4) tissue engineering (Dr. Mooney), (5) bioengineering (Dr. Kohn), (6) macromolecular chemistry (Drs. Laine, Robenson, and Filisko), and (7) ceramics (Drs. Tien and O'Brien), as well as D.D.S.-Ph.D. degrees in (8) biocompatibility (Dr. Hanks) and (9) oral pathology (Dr. Feigal), and D.D.S.-M.S. in (10) prosthodontics (Dr. Koran) and (11) clinical research design (Dr. Dennison). In the past, 19 Ph.D. and 42 M.S. degrees have been awarded through this program to many who have become leaders in the field. The future emphasis will be on training students for Ph.D. degrees and two positions will be allotted for trainees preparing for careers in clinical research. The program is managed by the Program Director, an Advisory Committee, and Admission Committee and Academic Advisors. All trainees will be required to take a seminar, Culture of Science, which includes scientific integrity as a major theme. The Program Director reports directly to the Dean of the School of Dentistry, who strongly supports this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007057-22
Application #
2683947
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1976-07-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
22
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Gupte, Melanie J; Swanson, W Benton; Hu, Jiang et al. (2018) Pore size directs bone marrow stromal cell fate and tissue regeneration in nanofibrous macroporous scaffolds by mediating vascularization. Acta Biomater 82:1-11
Saera-Vila, Alfonso; Louie, Ke'ale W; Sha, Cuilee et al. (2018) Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors. PLoS One 13:e0192214
Dame, Michael K; Attili, Durga; McClintock, Shannon D et al. (2018) Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development 145:
Donnelly, Christopher R; Gabreski, Nicole A; Suh, Esther B et al. (2018) Non-canonical Ret signaling augments p75-mediated cell death in developing sympathetic neurons. J Cell Biol 217:3237-3253
Kwon, Edwin K; Louie, Ke'ale; Kulkarni, Anshul et al. (2018) The Role of Ellis-Van Creveld 2(EVC2) in Mice During Cranial Bone Development. Anat Rec (Hoboken) 301:46-55
Juliar, Benjamin A; Keating, Mark T; Kong, Yen P et al. (2018) Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels. Biomaterials 162:99-108
Donnelly, Christopher R; Shah, Amol A; Mistretta, Charlotte M et al. (2018) Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proc Natl Acad Sci U S A 115:E516-E525
Patton, Daniella M; Bigelow, Erin M R; Schlecht, Stephen H et al. (2018) The relationship between whole bone stiffness and strength is age and sex dependent. J Biomech :
Mehta, Pooja; Novak, Caymen; Raghavan, Shreya et al. (2018) Self-Renewal and CSCs In Vitro Enrichment: Growth as Floating Spheres. Methods Mol Biol 1692:61-75
Michalski, Megan N; Seydel, Anna L; Siismets, Erica M et al. (2018) Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. FASEB J 32:3730-3741

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