The purpose of this training program is to provide a stimulating environment for interdisciplinary studies leading to Ph.D. or M.S. degrees in the field of dental biomaterials. The main themes for study include: (a) the synthesis, characterization and physical phenomena related to the behavior of biomaterials in service; (b) the biological interactions between materials and living cells; and (c) experimental design of laboratory and clinical investigations. Resources for accomplishing these three goals include the Horace H. Rackham School of Graduate Studies, the Materials Science and Engineering Department and the Bioengineering Program in the School of Engineering, the Biostatistics Department in the School of Public Health, the Oral Health Sciences Program in the School of Dentistry, Clinical Research Centers in the School of Dentistry, the Biomaterials Properties Database on the Internet, and an NIDR Specialized Materials Science Research Center (SMSRC) Grant. Projects in the SMSRC include ceramics (strengthening by hydration of glasses and controlled crystallization of leucite; near net shape forming for greater accuracy; new calcium aluminate cements), composites (alignment of filler particles with electric fields, reduction of curing shrinkage with microballoons, synthesis of liquid crystalline (LC)/silsesquixoxane copolymers), and biocompatibility (assessments of new restorative materials). The training faculty have an important diversity of backgrounds having Ph.D. degrees in (1) dental biomaterials (Dr. O'Brien), (2) analytical chemistry (Dr. Morris), (3) metallurgy (Dr. O'Brien), (4) tissue engineering (Dr. Mooney), (5) bioengineering (Dr. Kohn), (6) macromolecular chemistry (Drs. Laine, Robenson, and Filisko), and (7) ceramics (Drs. Tien and O'Brien), as well as D.D.S.-Ph.D. degrees in (8) biocompatibility (Dr. Hanks) and (9) oral pathology (Dr. Feigal), and D.D.S.-M.S. in (10) prosthodontics (Dr. Koran) and (11) clinical research design (Dr. Dennison). In the past, 19 Ph.D. and 42 M.S. degrees have been awarded through this program to many who have become leaders in the field. The future emphasis will be on training students for Ph.D. degrees and two positions will be allotted for trainees preparing for careers in clinical research. The program is managed by the Program Director, an Advisory Committee, and Admission Committee and Academic Advisors. All trainees will be required to take a seminar, Culture of Science, which includes scientific integrity as a major theme. The Program Director reports directly to the Dean of the School of Dentistry, who strongly supports this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007057-25
Application #
6483301
Study Section
NIDCR Special Grants Review Committee (DSR)
Program Officer
Lipton, James A
Project Start
1976-07-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
25
Fiscal Year
2001
Total Cost
$52,626
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Donnelly, Christopher R; Shah, Amol A; Mistretta, Charlotte M et al. (2018) Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proc Natl Acad Sci U S A 115:E516-E525
Patton, Daniella M; Bigelow, Erin M R; Schlecht, Stephen H et al. (2018) The relationship between whole bone stiffness and strength is age and sex dependent. J Biomech :
Mehta, Pooja; Novak, Caymen; Raghavan, Shreya et al. (2018) Self-Renewal and CSCs In Vitro Enrichment: Growth as Floating Spheres. Methods Mol Biol 1692:61-75
Michalski, Megan N; Seydel, Anna L; Siismets, Erica M et al. (2018) Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. FASEB J 32:3730-3741
Ochyl, Lukasz J; Bazzill, Joseph D; Park, Charles et al. (2018) PEGylated tumor cell membrane vesicles as a new vaccine platform for cancer immunotherapy. Biomaterials 182:157-166
Murakami, Tomoyuki; Kim, Jiwon; Li, Yi et al. (2018) Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nat Commun 9:2436
Miller, Alyssa J; Hill, David R; Nagy, Melinda S et al. (2018) In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells. Stem Cell Reports 10:101-119
Mahoney, Patrick; Miszkiewicz, Justyna J; Chapple, Simon et al. (2018) The biorhythm of human skeletal growth. J Anat 232:26-38
Kramer, Kaitrin; Yang, Jingwen; Swanson, W Benton et al. (2018) Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model. Genesis 56:e23220
Larsson, Lena; Pilipchuk, Sophia P; Giannobile, William V et al. (2018) When epigenetics meets bioengineering-A material characteristics and surface topography perspective. J Biomed Mater Res B Appl Biomater 106:2065-2071

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