This is an application for renewal of a NRSA training program in the field of periodontal diseases which is designed to train dentists to become both independent investigators and periodontists. Trainees will be expected to complete formal training in periodontics leading to a certificate as well as formal graduate training leading to the PhD degree. The training program is designed to provide the academic community with individuals capable of conducting independent research, managing a group of multidisciplined researchers to solve problems related to the epidemiology, etiology, pathogenesis, prevention and treatment of periodontal diseases, as well as individuals capable of leading pre- and postdoctoral teaching programs. Each trainee will complete a core curriculum in basic sciences which includes microbiology, biochemistry, immunology, and biostatistics. In addition, courses in cariology, mucosal immunity, saliva and salivary glands, as well as courses directly related to periodontology, will be included. Trainees will have the opportunity to rotate through various laboratories in order to find a suitable research discipline and mentor. Research training opportunities at Eastman Dental Center will be available in the Departments of Periodontology, Oral Biology and Community Dentistry. Research training opportunities at the University of Rochester will be available in the Departments of Dental Research, Biophysics, Microbiology-Immunology, Physiology, Biochemistry, Pathology, Pharmacology, Psychology, Neurobiology, and Anatomy. The awarding of the PhD follows successful research training, completion of a qualifying examination, and defense of a thesis. The program will be directed by Dr. Jack Caton with twelve co-advisors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007061-23
Application #
2896942
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1977-07-01
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
23
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Rochester
Department
Dentistry
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Harris, Sarah G; Padilla, Josue; Koumas, Laura et al. (2002) Prostaglandins as modulators of immunity. Trends Immunol 23:144-50
Padilla, Josue; Leung, Edmund; Phipps, Richard P (2002) Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. Clin Immunol 103:22-33
Padilla, J; Kaur, K; Cao, H J et al. (2000) Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol 165:6941-8
Padilla, J; Kaur, K; Harris, S G et al. (2000) PPAR-gamma-mediated regulation of normal and malignant B lineage cells. Ann N Y Acad Sci 905:97-109
Borrello, M A; Phipps, R P (1999) Fibroblast-secreted macrophage colony-stimulating factor is responsible for generation of biphenotypic B/macrophage cells from a subset of mouse B lymphocytes. J Immunol 163:3605-11
Romano, P R; Wang, J; O'Keefe, R J et al. (1998) HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. J Cell Sci 111 ( Pt 6):803-13
Ostberg, J R; Dragone, L L; Borrello, M A et al. (1997) Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T-independent antigens. Eur J Immunol 27:2152-9
Romano, P R; Caton, J G; Puzas, J E (1997) The reversal line may be a key modulator of osteoblast function: observations from an alveolar bone wound-healing model. J Periodontal Res 32:143-7
Lowenguth, R A; Polson, A M; Caton, J G (1993) Oriented cell and fiber attachment systems in vivo. J Periodontol 64:330-42
Blieden, T M; Caton, J G; Proskin, H M et al. (1992) Examiner reliability for an invasive gingival bleeding index. J Clin Periodontol 19:262-7

Showing the most recent 10 out of 34 publications