This application seeks renewal of a NRSA training program to train predoctoral students, postgraduate students, and graduate students in periodontal diseases and chronic inflammation. The program is designed to provide a broad spectrum of multi-disciplinary basic and clinical training opportunities that will produce researchers capable of patient-oriented and patient-related research on periodontal and other inflammatory diseases of the oral cavity. The content, level and length of training are designed to produce individuals with a substantive foundation for a competitive research career who can assume university faculty positions where they will teach and conduct independent research relevant to oral health and disease, or fill key research positions in industry. Training will be in the content and use of modern ideas and methods of molecular biology, behavioral science, and bioengineering in investigation of chronic inflammatory periodontal disease. The program is unique in that it pulls together under the Research Center in Oral Biology the training potential of Periodontics, a major clinical department of the School of Dentistry, the Departments of Biochemistry, Microbiology, Immunology, Biological Structure, Pathology, and the Center for Bioengineering of the School of Medicine, the Department of Pathobiology of the School of Public Health and Community Medicine, and the Department of Psychology of the School of Arts and Sciences. Most of the participating faculty have worked together for more than one or two decades to conduct this training program over the last 20 years. Three types of trainees will be recruited: predoctoral trainees who will pursue a PhD degree, dentists who also have training in periodontics and seek advanced degree training, and dentists who seek combined training in periodontics and advanced degree training. On occasion, an individual with a PhD may receive postdoctoral training. The program will be under the leadership of Dr. Roy C. Page who will work with 21 participating faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007063-24
Application #
2896943
Study Section
NIDCR Special Grants Review Committee (DSR)
Project Start
1976-07-01
Project End
2001-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
24
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Dentistry
Type
Schools of Dentistry
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Luna, Vicki A; Heiken, Marc; Judge, Kathleen et al. (2002) Distribution of mef(A) in gram-positive bacteria from healthy Portuguese children. Antimicrob Agents Chemother 46:2513-7
Brissette, Catherine A; Lukehart, Sheila A (2002) Treponema denticola is resistant to human beta-defensins. Infect Immun 70:3982-4
Fan, Q; Sims, T; Sojar, H et al. (2001) Fimbriae of Porphyromonas gingivalis induce opsonic antibodies that significantly enhance phagocytosis and killing by human polymorphonuclear leukocytes. Oral Microbiol Immunol 16:144-52
Fan, Q; Sims, T J; Nakagawa, T et al. (2000) Antigenic cross-reactivity among Porphyromonas gingivalis serotypes. Oral Microbiol Immunol 15:158-65
Page, R C (2000) Vaccination and periodontitis: myth or reality. J Int Acad Periodontol 2:31-43
Page, R C (1998) The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Ann Periodontol 3:108-20
Gu, K; Bainbridge, B; Darveau, R P et al. (1998) Antigenic components of Actinobacillus actinomycetemcomitans lipopolysaccharide recognized by sera from patients with localized juvenile periodontitis. Oral Microbiol Immunol 13:150-7
Page, R C (1998) Periodontal diseases: a new paradigm. J Dent Educ 62:812-21
Wasteson, Y; Roe, D E; Falk, K et al. (1996) Characterization of tetracycline and erythromycin resistance in Actinobacillus pleuropneumoniae. Vet Microbiol 48:41-50
Roberts, M C; Chung, W O; Roe, D E (1996) Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola. Antimicrob Agents Chemother 40:1690-4

Showing the most recent 10 out of 46 publications