In response to the NIDCR's call for institutional training programs to produce skilled and versatile scientists who can address the opportunities and challenges in dental, oral and craniofacial research a Comprehensive T32 NRSA Institutional Training Grant in Oral Biology is proposed. The proposal is a continuation of a T32 Training Grant in Oral Biology at the University of Florida. This broad based training program in basic and clinical biomedical investigations in oral biology will help to satisfy the continuing need for basic, multidisciplinary biomedical oral health research and to remedy the serious shortage of clinician/scientist and translational, patient oriented oral and craniofacial researchers. A combination of well funded, basic and clinical researchers have been brought together to provide a variety of training opportunities in biomedical sciences relevant to issues in oral health. The focus of the research training will be in oral bacterial and mycotic infectious diseases, host parasite interactions, vaccine strategies, relevant autoimmune diseases, connective tissue biology, gene therapy, and dental/craniofacial clinical research.
The specific aims of this proposal are: 1) to produce basic multidisciplinary biomedical scientists to do research on issues of oral health;2) to produce patient oriented dental clinician scientists;3) to produce clinician scientists with a PhD and dental specialty training;4) to provide clinical investigation training to produce dental clinical and translation researchers;and 5) to provide short-term experiences for dental students and dental faculty in clinical investigation and basic dental and craniofacial research to promote their interest and success in careers as clinician scientists. Interdisciplinary research training programs in the Colleges of Dentistry and Medicine will be utilized. Research training resources include the PhD Interdisciplinary Program in Biomedical Sciences, an Advanced Professional Program in Clinical Investigation, the General Clinical Research Center and well funded basic and clinical biomedical scientists. By using combinations of these and other resources, an integrated and flexible training program is offered that will meet the needs of a variety of trainees and have maximum potential to produce a """"""""cadre of highly skilled and interactive scientists"""""""" who can successfully devise and test new knowledge to advance the detection, treatment, prevention and cure of diseases and abnormalities of the oral and craniofacial structures. Relevance. Oral diseases are some of the most wide spread diseases in the human population. They can result in severe physical and psychological discomfort, financial hardship, and negatively affect a person's general health. Continued research is needed to detect, treat and prevent oral diseases to improve the well being of the human population. This training grant will produce basic and clinical scientists who will develop and implement new methods to improve oral health World-wide.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007200-19
Application #
7630516
Study Section
Special Emphasis Panel (ZDE1-LK (28))
Program Officer
Hardwick, Kevin S
Project Start
1990-09-30
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
19
Fiscal Year
2009
Total Cost
$661,900
Indirect Cost
Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Shaddox, Luciana M; Spencer, William P; Velsko, Irina M et al. (2016) Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque. J Clin Periodontol 43:746-53
Seaton, Kinda; Ahn, Sang-Joon; Burne, Robert A (2015) Regulation of competence and gene expression in Streptococcus mutans by the RcrR transcriptional regulator. Mol Oral Microbiol 30:147-159
Dominguez-Gutierrez, Paul R; Ceribelli, Angela; Satoh, Minoru et al. (2014) Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Arthritis Res Ther 16:R23
Dominguez-Gutierrez, Paul R; Ceribelli, Angela; Satoh, Minoru et al. (2014) Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus. J Clin Immunol 34:171-80
Robinette, Rebekah A; Heim, Kyle P; Oli, Monika W et al. (2014) Alterations in immunodominance of Streptococcus mutans AgI/II: lessons learned from immunomodulatory antibodies. Vaccine 32:375-82
Brown, Heather M; Knowlton, Andrea E; Snavely, Emily et al. (2014) Multinucleation during C. trachomatis infections is caused by the contribution of two effector pathways. PLoS One 9:e100763
Neiva, K G; Calderon, N L; Alonso, T R et al. (2014) Type 1 diabetes-associated TLR responsiveness of oral epithelial cells. J Dent Res 93:169-74
Dominguez-Gutierrez, Paul R; Ceribelli, Angela; Satoh, Minoru et al. (2014) Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther 16:R20
King, Christopher D; Goodin, Burel; Glover, Toni L et al. (2013) Is the pain-reducing effect of opioid medication reliable? A psychophysical study of morphine and pentazocine analgesia. Pain 154:476-83
Toro, E J; Zuo, J; Gutierrez, A et al. (2013) Bis-enoxacin inhibits bone resorption and orthodontic tooth movement. J Dent Res 92:925-31

Showing the most recent 10 out of 86 publications