This is a competing renewal application for a T32 grant that supports Training in Craniofacial and Oral Health Research (T-COHR), an integrated research training program based in the College of Dental Medicine at the Medical University of South Carolina (MUSC). The overarching objective of T-COHR is to foster the development of clinician scientists and scientists focused on oral, dental and craniofacial research. To accomplish this goal, T-COHR offers mentored, interdisciplinary research training opportunities in oral health, craniofacial biology and bioengineering. T-COHR provides a strong curriculum and thematic research experiences in an integrative framework that emphasizes mentoring, scientific advancement, academic career development, grantsmanship, and productivity. For this renewal period, we are requesting (1) continued support for the Dental Scientist Training Program (DSTP), offering a consolidated DMD/PhD degree pathway; (2) continued support for predoctoral research training leading to the PhD degree in biomedical sciences or bioengineering with applications to oral/craniofacial health; and (3) continued support for postdoctoral research training for dentist-scientists and/or non-clinician PhD scientists in basic, translational or bioengineering sciences important to dental, oral or craniofacial health. T-COHR is an integral part of the Center for Oral Health Research (COHR), a University Center of Research Excellence in the College of Dental Medicine that engages faculty and trainees in other disciplines and departments in the Colleges of Medicine, Graduate Studies, Pharmacy and Dental Medicine at MUSC, the Department of Bioengineering at Clemson University, and the NCI-designated Hollings Cancer Center at MUSC. Mentoring and training activities are thematically grouped into 4 strategic areas of research focus: (i) molecular and cellular biology of oral infectious diseases, (ii) oral pharyngeal cancer biology and cancer immunology, (iii) bioengineering/biomechanics of the oral and craniofacial complex, and (iv) craniofacial growth and development. T-COHR benefits from excellent administrative support and institutional commitment that have provided continued support to the Center for Oral Health Research. An integrated multi-year evaluation plan will be used to measure the extent to which T- COHR goals and objectives are met.

Public Health Relevance

In the United States, there remains a critical need for well-trained investigators in dental, oral and craniofacial research. This training grant application supports Training in Craniofacial and Oral Health Research (T-COHR), an integrated program based in the College of Dental Medicine at the Medical University of South Carolina (MUSC) to help train the next generation of clinician scientists and scientists engaged in dental, oral and craniofacial research. Research training will be in the areas of oral infection and inflammation, oral cancer, bioengineering/biomechanics and oral/craniofacial complex growth and regeneration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE017551-12
Application #
9304994
Study Section
Special Emphasis Panel (ZDE1)
Program Officer
King, Lynn M
Project Start
2006-07-01
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
12
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29403
Cisewski, Sarah E; Wu, Yongren; Damon, Brooke J et al. (2018) Comparison of Oxygen Consumption Rates of Nondegenerate and Degenerate Human Intervertebral Disc Cells. Spine (Phila Pa 1976) 43:E60-E67
Durham, Emily L; Howie, R Nicole; Hall, SarahRose et al. (2018) Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold. J Transl Med 16:321
She, Xin; Wei, Feng; Damon, Brooke J et al. (2018) Three-dimensional temporomandibular joint muscle attachment morphometry and its impacts on musculoskeletal modeling. J Biomech 79:119-128
Lee, Jungnam; Roberts, JoAnn S; Atanasova, Kalina R et al. (2018) A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27. Cell Microbiol 20:e12825
Lee, Jaden S; Yilmaz, Özlem (2018) Unfolding Role of a Danger Molecule Adenosine Signaling in Modulation of Microbial Infection and Host Cell Response. Int J Mol Sci 19:
Wright, Gregory J; Coombs, Matthew C; Wu, Yongren et al. (2018) Electrical Conductivity Method to Determine Sexual Dimorphisms in Human Temporomandibular Disc Fixed Charge Density. Ann Biomed Eng 46:310-317
Howie, R Nicole; Durham, Emily; Oakes, Brayden et al. (2018) Testing a novel nanofibre scaffold for utility in bone tissue regeneration. J Tissue Eng Regen Med 12:2055-2066
Howie, R Nicole; Herberg, Samuel; Durham, Emily et al. (2018) Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. Int J Oral Sci 10:25
Lee, Kyulim; Roberts, JoAnn S; Choi, Chul Hee et al. (2018) Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells. Virulence 9:845-859
Thomas, Raquela J; Oleinik, Natalia; Panneer Selvam, Shanmugam et al. (2017) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med 9:1030-1051

Showing the most recent 10 out of 65 publications