This proposal seeks continued support for the Yale research training program in Diabetes Mellitus and Disorders of Metabolism. This program serves as the core support for postdoctoral research training in diabetes and endocrinology at the Yale School of Medicine. The application requests an additional training slot per year for a total of 6 annual stipends. The request is based on our track record of attracting a strong applicant pool, the high level of research productivity of our training faculty, the expanded size of the training faculty offering opportunities for diabetes and metabolic disease research, and the continuing shortage of physician-scientists in both adult and pediatric diabetes and endocrinology. A major goal of the program is to develop physician-scientists who possess the requisite laboratory skills to pursue research careers in an academic setting. Physician trainees entering the program will have an M.D. or M.D./PhD degrees and at least 2-3 years of clinical training in medicine or pediatrics. PhD scientists are also recruited to the program since we believe that their participation is critical to the training environment. Emphasis in the selection of trainees is given to those applicants demonstrating aptitude and commitment to a research career. The duration of the training period is three years to ensure an in-depth training experience. The cornerstone of the curriculum involves the participation of the trainee in a specific laboratory project under the supervision of a designated preceptor. Each trainee is also guided by a progress committee composed of 3 other members of the training faculty. The research projects offered span the gamut from clinical to basic research in 3 primary areas of emphasis: 1) type 1 diabetes, 2) type 2 diabetes, and 3) bone and mineral metabolism. Within these areas, trainees have the opportunity to work with mentors in several different basic science departments as well as those in medicine and pediatrics. Close interaction among preceptors within each programmatic area and within 6 multidisciplinary and interdepartmental research centers administered within the Endocrine Section further enrich the training experience. Instruction is also provided through organized lectures, research seminars and journal clubs. Obesity, diabetes and osteoporosis represent a spectrum of metabolic disease that causes a great deal of suffering and death. Academic endocrine researchers are needed to better understand these disorders and to translate research findings into new therapies. Our training program is dedicated to providing young physicians and scientists with the training necessary to tackle these important health problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007058-36
Application #
7797354
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2014-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
36
Fiscal Year
2010
Total Cost
$351,520
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Erie, Christine; Van Name, Michelle A; Weyman, Kate et al. (2018) Schooling diabetes: Use of continuous glucose monitoring and remote monitors in the home and school settings. Pediatr Diabetes 19:92-97
Hwang, Janice J; Jiang, Lihong; Hamza, Muhammad et al. (2017) The human brain produces fructose from glucose. JCI Insight 2:e90508
Naushad, Nida; Perdigoto, Ana Luisa; Rui, Jinxiu et al. (2017) Have we pushed the needle for treatment of Type 1 diabetes? Curr Opin Immunol 49:44-50
Sanchez-Rangel, Elizabeth; Inzucchi, Silvio E (2017) Metformin: clinical use in type 2 diabetes. Diabetologia 60:1586-1593
Hwang, Janice J; Jiang, Lihong; Hamza, Muhammad et al. (2017) Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2:
Rui, Jinxiu; Deng, Songyan; Arazi, Arnon et al. (2017) ? Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metab 25:727-738
Naik, Sarita; Belfort-DeAguiar, Renata; Sejling, Anne-Sophie et al. (2017) Evaluation of the counter-regulatory responses to hypoglycaemia in patients with type 1 diabetes during opiate receptor blockade with naltrexone. Diabetes Obes Metab 19:615-621
Kim, Wonnam; Takyar, Farzin M; Swan, Karena et al. (2016) Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res 76:5348-60
Jeong, Jaekwang; VanHouten, Joshua N; Dann, Pamela et al. (2016) PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A 113:E282-90
Belfort-DeAguiar, R; Seo, D; Naik, S et al. (2016) Food image-induced brain activation is not diminished by insulin infusion. Int J Obes (Lond) 40:1679-1686

Showing the most recent 10 out of 47 publications