This renewal proposal requests five additional years of support (years 38-43) for the University of California, Los Angeles Training Grant in Gastroenterology. Support is sought to maintain the trainees at the same level: six (either MD's or PhD's). One additional NIH minority supplement will be requested as needed. These trainees will be recruited from the UCLA STAR (Specialized Training in Academic Research), the UCLA Affiliated Fellowship Training Program in Gastroenterology, or from UCLA affiliated Ph.D. training programs. This NIH T32 Training Grant has been funded continuously since 1974, and Dennis M. Jensen, M.D. has been the PI/Director since 2000. In the last 10 years of this training grant, 30 trainees have been (or will soon be) enrolled. 23 have completed this T32 training and 1 will be finishing June 30, 2010. These 24 T32 trainees included 20 MD's, 2 PhD's, and 2 MD/PhD's. For the 23 T32 trainees who have previously finished participation in this grant, 100% completed at least 2 years of research training, and 61% obtained further support for research and/or career development. For the 57% with further career development awards, these included 22 % with one or more independent NIH awards (as K08 or K23 grants);4% who received VA awards (VA HSR&D), and 31% who were awarded other career development awards (CCFA, ADHF, or California Cancer Institute). Of the 24 T32 trainees who will have graduated by July 2010, 96% published at least one peer- reviewed research paper. For those who published, the median number of publications per trainee of research performed during their T32 years was 6 (range 2 - 63). For these 24 trainees, additional degrees completed during T32 training are 4 PhD's and 7 Master degrees (MS or MPH). Among the 23 trainees who have already completed all their post-MD training, 16 (70%) now hold academic or research appointments and positions. The administrative structure of the Training Grant has evolved during the past 10 years to maximize productivity and satisfaction plus emphasize successful career paths for all trainees. The leadership of this training grant is well balanced. The PI is a clinical and outcomes researcher, one co-PI is a basic scientist (Stephen Pandol, MD), and the other is a translational researcher (Peter Anton, MD). The Executive Committee of the Training Grant ensures that all research trainees are closely supervised and allowed to give feed-back throughout their career development. Trainees are exposed to formal courses and research seminars to expand their scientific knowledge base. The UCLA STAR program has the added dimension of requiring Masters or Ph.D. degrees as part of the research training and career development. This training serves as the foundation and model for a highly evolved and successful UCLA Research Training Program in Gastroenterology. Continued support is needed to maintain the quality and productivity of this program which is training future academicians in digestive diseases.

Public Health Relevance

This training grant supports post-graduate mentored research for the next generation of academic leaders and researchers in digestive diseases and gastroenterology (GI). Digestive complaints, disorders, and diseases are very common in the United States and highly relevant to the public health because they cause significant morbidity and health care costs for them are very high. Improvements in our understanding and knowledge of digestive disorders and discovery in this field have the potential of significantly improving public health.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (J2))
Program Officer
Densmore, Christine L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Videlock, Elizabeth J; Mahurkar-Joshi, Swapna; Hoffman, Jill M et al. (2018) Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol 315:G140-G157
Jacob, Noam; Jacobs, Jonathan P; Kumagai, Kotaro et al. (2018) Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol 11:1466-1476
Park, S H; Naliboff, B D; Shih, W et al. (2018) Resilience is decreased in irritable bowel syndrome and associated with symptoms and cortisol response. Neurogastroenterol Motil 30:
Xu, Mu; Jung, Xiaoman; Hines, O Joe et al. (2018) Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss. Pancreas 47:158-162
Dong, Tien; Pisegna, Joseph (2018) Passing the ""Acid Test"": Do Proton Pump Inhibitors Affect the Composition of the Microbiome? Dig Dis Sci :
Jacobs, Jonathan P; Lin, Lin; Goudarzi, Maryam et al. (2017) Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes 8:1-16
Benhammou, Jihane N; Phan, Jennifer; Lee, Hane et al. (2017) A Sodium Channel Myotonia Presenting with Intermittent Dysphagia as a Manifestation of a Rare SCN4A Variant. J Mol Neurosci 61:312-314
Wang, Jeremy; Benhammou, Jihane N; Ghassemi, Kevin et al. (2017) Endoscopic Ultrasound-Guided Fine Needle Aspiration Accurately Diagnoses Smaller Pancreatic Neuroendocrine Tumors Compared To Computer Tomography-Guided Fine Needle Aspiration. J Gastroenterol Pancreatol Liver Disord 4:1-7
Jackson, Samuel B; Villano, Nicholas P; Benhammou, Jihane N et al. (2017) Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature. Dig Dis Sci 62:2623-2630
May, Folasade P; Reid, Mark W; Cohen, Samuel et al. (2017) Predictive overbooking and active recruitment increases uptake of endoscopy appointments among African American patients. Gastrointest Endosc 85:700-705

Showing the most recent 10 out of 91 publications