In this renewal application of an established (42 years), successful multidisciplinary training program in Digestive Diseases, we will continue to train qualified postdoctoral individuals (M.D., and/or Ph.D.) for academic careers in digestive diseases. Our interdisciplinary, full time faculty of 36 scientists supports two tracks for potential trainees: i) basic/disease oriented research; and ii) patient-oriented research. The basic/disease oriented track remains one of long-standing excellence with training opportunities in mucosal immunology, cell biology, enteric neurosciences, liver pathobiology, and new opportunities organized around regenerative medicine/stem cells and transcription/epigenetics. Training in this track is strongly supported through interactions with the NIH funded Mayo Comprehensive Cancer Center, Basic Science Departments at Mayo Clinic, and the NIH P30 Digestive Disease Center grant. The patient-oriented track, which is educationally buttressed through the Mayo Center for Translational Science Activities (CTSA), maintains training opportunities in human genetics/epidemiology, obesity/nutrition, human imaging/physiology, and the science of healthcare delivery/comparative effectiveness, the latter being a new area of institutional focus. We continue to request support for 5 postdoctoral trainees/year that are selected through objective and consensus-driven mechanisms from a talented annual pool of approximately 100 M.D., PhD, or M.D./PhD candidates derived from a variety of clinical and basic disciplines. The overall success of the program continues to be outstanding with 85% of trainees from the most recently completed 10-year cohort (n=24) entering into an academic medicine staff appointment and a funding portfolio from this cohort that includes 13 new federal grants (4 K series, 5 R series, 4 P30 pilots). Understanding the positive impact of diversity on the training environment and outcomes, we are currently experiencing our most diverse chapter in our history. Over the current reporting period 50% of the trainees are women and 32% of appointments were filled with applicants of Diverse Backgrounds. Institutional support also continues to be strong and well documented. Thus, this highly established training program remains creative, innovative, and dynamic, thereby continuing to be highly successful in achieving its goal of training individuals for academic careers in gastroenterology and hepatology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007198-45
Application #
9859383
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1979-01-01
Project End
2023-12-31
Budget Start
2020-01-01
Budget End
2020-12-31
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Yang, Ju Dong; Addissie, Benyam D; Mara, Kristin C et al. (2018) GALAD Score for Hepatocellular Carcinoma Detection in Comparison to Liver Ultrasound and Proposal of GALADUS Score. Cancer Epidemiol Biomarkers Prev :
Yang, Ju Dong; Mannalithara, Ajitha; Piscitello, Andrew J et al. (2018) Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis. Hepatology 68:78-88
Hicks, S B; Tabibian, J H (2017) Molecular Adsorbent Recirculating System as a Diagnostic and Therapeutic Modality. J Mol Genet Med 11:
Yang, Ju Dong; Dai, Jianliang; Singal, Amit G et al. (2017) Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase. Cancer Epidemiol Biomarkers Prev 26:1085-1092
Wang, Ruisi; Ding, Qian; De Assuncao, Thiago M et al. (2017) Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. Am J Pathol 187:134-145
Maiers, Jessica L; Kostallari, Enis; Mushref, Malek et al. (2017) The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice. Hepatology 65:983-998
Yang, Ju Dong; Altekruse, Sean F; Nguyen, Mindie H et al. (2017) Impact of country of birth on age at the time of diagnosis of hepatocellular carcinoma in the United States. Cancer 123:81-89
Yang, Ju Dong; Ahmed Mohammed, Hager; Harmsen, William S et al. (2017) Recent Trends in the Epidemiology of Hepatocellular Carcinoma in Olmsted County, Minnesota: A US Population-based Study. J Clin Gastroenterol 51:742-748
Yang, Ju Dong; Larson, Joseph J; Watt, Kymberly D et al. (2017) Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United States. Clin Gastroenterol Hepatol 15:767-775.e3
Robinson, Matthew M; Dasari, Surendra; Konopka, Adam R et al. (2017) Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans. Cell Metab 25:581-592

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