The application is to renew the T32 application for a Training Program in Diabetes, Endocrinology and Metabolic Diseases from Boston University Medical Center that consists of Boston Medical Center and Boston University Medical School. This Program that has been funded by the NIH since 1964. During this period, numerous post-doctoral fellows have been trained by this Program, many of whom have gone on to successful careers in academia. More recently, the inclusion of pre-doctoral trainees has resulted in their having a similar rate of successful careers in academia. As the composition of the Boston University Medical Center faculty has changed, and the health problems of the population, local and nationwide, have evolved over these past ca. 50 years, the translational and basic research focus and strengths of the program have evolved to meet these changes. Thus, in the current application, we emphasize four Program areas for the training of post- and pre-doctoral scientists and physician/scientists in which we have considerable strength. These are: (i) basic (molecular, cellular endocrine and metabolic science related to obesity and diabetes) (ii) vascular biology and inflammation and its relationship to metabolic disease (iii) translational studies related to endocrine and metabolic disease (iv) model systems and organisms in regulation of metabolism. To address the major health-related issues in these areas, trainees will utilize a variety of relevant animal models, in vitro cell systems as well as bringing a major focus to human metabolism at both the cellular and organismal levels. Trainees will be able to understand multiple aspects of metabolic diseases in one or more of the areas noted above, and they will be able to apply this understanding in a translational fashion to disease prevention, treatment and eventual cure. The need for such training is underscored by the explosion of metabolic disease, not only in the USA, but worldwide. The training team consists of scientists, clinicians and physician/scientists, in multiple departments at BU Medical Center, who are highly accomplished, interactive and broadly experienced. Consequently, trainees will have access to state of the art knowledge, resources and technology provided to them by cutting edge investigators.

Public Health Relevance

Obesity and diabetes mellitus, and their associated pathologies, represent worldwide epidemics with enormous physical and social costs. By training the next generation of translational researchers at the pre- doctoral and post-doctoral levels, we will stem the tide by the prevention and treatment of these metabolic disorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
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Boston Medical Center
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Lin, Jean Z; Rabhi, Nabil; Farmer, Stephen R (2018) Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. Cell Rep 23:1977-1987
Benador, Ilan Y; Veliova, Michaela; Mahdaviani, Kiana et al. (2018) Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab 27:869-885.e6
Thomas, Dylan D; Istfan, Nawfal W; Bistrian, Bruce R et al. (2018) Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science. Metabolism 79:83-96
Zaarur, Nava; Pan, Xiang; Kandror, Konstantin V (2018) Detection of Detergent-sensitive Interactions Between Membrane Proteins. J Vis Exp :
Stockman, Mary-Catherine; Thomas, Dylan; Burke, Jacquelyn et al. (2018) Intermittent Fasting: Is the Wait Worth the Weight? Curr Obes Rep 7:172-185
Thomas, Dylan D; Anderson, Wendy A; Apovian, Caroline M et al. (2018) Weight Recidivism After Roux-en-Y Gastric Bypass Surgery: An 11-Year Experience in a Multiethnic Medical Center. Obesity (Silver Spring) :
Mahdaviani, Kiana; Benador, Ilan Y; Su, Shi et al. (2017) Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep 18:1123-1138
Pan, Xiang; Zaarur, Nava; Singh, Maneet et al. (2017) Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell 28:1667-1675
Lee, Sun Y; Stagnaro-Green, Alex; MacKay, Douglas et al. (2017) Iodine Contents in Prenatal Vitamins in the United States. Thyroid 27:1101-1102
Nicholas, Dequina A; Andrieu, Guillaume; Strissel, Katherine J et al. (2017) BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci 74:231-243

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