The aim of this three-year research training program is to develop independent investigators who will devote their career to research on fundamental aspects of gastrointestinal disease. The postdoctoral training involves three years of supervised, self-directed laboratory research aimed at developing in the trainee the ability to formulate meaningful scientific questions and hypotheses, design and conduct experiments to test hypothesis, and present results in oral and written form. Each trainee's postdoctoral research program is guided by the equivalent of a """"""""thesis committee"""""""" consisting of three members, two of who are not the trainee's direct mentor. Laboratory research is performed in the mentor's laboratory and supplemented, as appropriate, by didactic course work appropriate to the trainee's project. The program also offers predoctoral training for Ph.D. candidates within the laboratories of faculty members of the training grant under the auspices of the Biomedical Sciences and Molecular Pathology Graduate Programs. The training faculty includes basic scientists at UCSD and neighboring research institutes where there is close collaboration. The training program is enriched by a strong seminar program. Specialized research fields of the sponsoring faculty relevant to the program include: (a) regulation of the immune response; (b) mechanisms of intracellular signaling; (c) regulation of cell growth and differentiation; (d) molecular basis of disease and gene therapy; (e) regulation of gene transcription; (f) intracellular trafficking; (g) regulation of electrolyte secretion; (h) regulation of the inflammatory response and (i) host-microbial pathogenesis. The program is designed for graduate students, M.D.s or Ph.D.s who are committed to an academic career in the gastroenterological sciences. The resources available are extensive and well funded. Special efforts are made to attract minority candidates. Trainees are instructed in the ethical conduct of research. At the completion of the program, the postdoctoral trainees should be competitive for entry level independent funding and predoctoral trainees will be highly competitive for outstanding postdoctoral positions.
| Klann, Jane E; Kim, Stephanie H; Remedios, Kelly A et al. (2018) Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol 200:4012-4023 |
| Fumery, Mathurin; Singh, Siddharth; Dulai, Parambir S et al. (2018) Natural History of Adult Ulcerative Colitis in Population-based Cohorts: A Systematic Review. Clin Gastroenterol Hepatol 16:343-356.e3 |
| Loomba, Rohit; Seguritan, Victor; Li, Weizhong et al. (2017) Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metab 25:1054-1062.e5 |
| Singh, Siddharth; Dulai, Parambir S; Zarrinpar, Amir et al. (2017) Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes. Nat Rev Gastroenterol Hepatol 14:110-121 |
| Annamalai, Alagappan; Harada, Megan Y; Chen, Melissa et al. (2017) Predictors of Mortality in the Critically Ill Cirrhotic Patient: Is the Model for End-Stage Liver Disease Enough? J Am Coll Surg 224:276-282 |
| Stein, Lance L; Tully, Madeline C; Arepally, Aravind (2017) Transarterial Chemoembolization vs Yttrium-90 Transarterial Radioembolization. Gastroenterology 152:1623-1624 |
| Widjaja, Christella E; Olvera, Jocelyn G; Metz, Patrick J et al. (2017) Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest 127:3609-3623 |
| Klann, Jane E; Remedios, Kelly A; Kim, Stephanie H et al. (2017) Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol 198:4639-4651 |
| Hirten, Robert; Cohen, Benjamin L; Colombel, Jean-Frederic (2017) Colonic Pseudopolyps Resulting in Iron Deficiency Anemia. Clin Gastroenterol Hepatol 15:A27 |
| Butcher, Lindsay D; den Hartog, Gerco; Ernst, Peter B et al. (2017) Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. Cell Mol Gastroenterol Hepatol 3:316-322 |
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