This is a competitive renewal application for T32 DK07260, entitled """"""""Training Grant in Diabetes and Metabolism,"""""""" currently in its 25th year. This program provides multi-disciplinary training in diabetes research for predoctoral students and postdoctoral fellows (MD and/or PhD) at the Research Division of the Joslin Diabetes Center in Boston. Its rationale is: 1) that diabetes is currently a devastating world health problem from both a human and economic standpoint; 2) that the Joslin, given its rich history of diabetes research and its current breadth and excellence, is a unique environment for training the corps of researchers required to solve this problem; and 3) that the Joslin can already demonstrate an impressive research training record. The Program Director is Dr. Diane Mathis and Co-Director Dr. George King, who are supported by an Executive Committee. The postdoctoral training faculty consists of thirty-eight investigators at the Joslin Diabetes Center; the predoctoral faculty is primarily the subset holding appointments in the Division of Medical Sciences at Harvard Medical School. The individual Preceptors provide a mentor-based research experience that ranges from the most basic through the preclinical to the clinical, exploiting approaches that span the computational, biophysical, biochemical, molecular biological, cellular biological and organismic. Areas of focus include insulin signaling, intermediary metabolism, vascular cell biology, islet cell physiology, obesity, immunology, epidemiology, genetics, and mental health. Training is enhanced by Joslin's NIH-supported Diabetes and Endocrinology Research Center (DERC) and its strong ties with Harvard Medical School, both of which provide access to state-of-the-art technologies as well as to a core of lectures/seminars by leading scientists from around the world. The program currently supports five postdoctoral fellows and two predoctoral students; here support for a third predoctoral position is requested. This augmentation is justified by the increased vigor of Joslin's predoctoral component, with the recruitment of new investigators active in graduate education and the scientific maturation of others, signaled by a doubling of the number of predoctoral applications in 1999-2000 and tripling in 2000-2001. Support for two short-term predoctoral fellows is also requested, reflecting the strength of and interest in Joslin's Summer Research Training Program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007260-28
Application #
6784669
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
1977-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
28
Fiscal Year
2004
Total Cost
$265,166
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Bartelt, Alexander; Widenmaier, Scott B; Schlein, Christian et al. (2018) Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med 24:292-303
McGill, Dayna E; Volkening, Lisa K; Butler, Deborah A et al. (2018) Baseline Psychosocial Characteristics Predict Frequency of Continuous Glucose Monitoring in Youth with Type 1 Diabetes. Diabetes Technol Ther 20:434-439
Beverly, Elizabeth A; Ritholz, Marilyn D; Wray, Linda A et al. (2018) Understanding the Meaning of Food in People With Type 2 Diabetes Living in Northern Appalachia. Diabetes Spectr 31:14-24
Teló, G H; Dougher, C E; Volkening, L K et al. (2018) Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes. Diabet Med 35:1355-1363
Mulla, Christopher M; Middelbeek, Roeland J W; Patti, Mary-Elizabeth (2018) Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci 1411:53-64
McGill, Dayna E; Volkening, Lisa K; Pober, David M et al. (2018) Depressive Symptoms at Critical Times in Youth With Type 1 Diabetes: Following Type 1 Diabetes Diagnosis and Insulin Pump Initiation. J Adolesc Health 62:219-225
Gao, Fei; McDaniel, Justice; Chen, Emily Y et al. (2018) Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species. Lipids 53:133-142
Gordin, Daniel; Harjutsalo, Valma; Tinsley, Liane et al. (2018) Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 41:815-822
Lynes, Matthew D; Shamsi, Farnaz; Sustarsic, Elahu Gosney et al. (2018) Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Rep 24:781-790
Laguna Sanz, Alejandro J; Mulla, Christopher M; Fowler, Kristen M et al. (2018) Design and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia. Diabetes Technol Ther 20:127-139

Showing the most recent 10 out of 207 publications