? The overall objective of the Endocrinology Training Program at the University of Massachusetts Medical School for the past 30 year has been that of the NRSA, namely """"""""...to prepare qualified individuals for careers that significantly impact the Nation's research agenda."""""""" The Program's specific goal is to train both clinical (M.D.) and basic (Ph.D.) scientists whose research and/or academic patient care careers will improve the care and outcome of endocrine diseases and diabetes mellitus. The majority of our trainees have entered competitive careers in academic research, government, and industry during the past 30 years. ? The Program offers classical endocrinology and diabetes research opportunities, but in addition seeks to extend the breadth of the training offered to encompass cutting edge concepts, technologies, and programs that are clinical/translational in nature. The University of Massachusetts Medical School has undergone major expansion of facilities and research opportunities. New Program features capitalize on institutional growth, and the Program provides a rich research experience for talented, well-trained, and motivated postdoctoral trainees. Four areas are emphasized: immunology of diabetes and islet transplantation, neuroendocrinology, cell signaling, and developmental study of bone and gonad. All areas are at the forefront of national priorities in endocrine research. ? We propose again to support 3 M.D. and 3 Ph.D. trainees annually for 2-3 years each. All trainees will be individually mentored throughout their fellowships. A formal mentoring committee will continue to monitor each trainee's progress. A recruitment initiative to attract undergraduate medical students directly to the program will be continued and allow the start of research during residency. M.D. trainees will have access to graduate school coursework in molecular and cellular biology and Ph.D. trainees will attend special seminars to enhance their knowledge of the translation of basic research to the clinic. Program faculty comprise a lean 'core' of 18 scientists, each of whom is an extramurally funded authority in one of the areas of emphasis. We believe that the proposed organizational and educational program will continue to enhance the research experience of our trainees and address the nation's need for committed investigators and academics in these important areas of medical and research need. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007302-31
Application #
7434680
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1998-08-14
Project End
2013-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
31
Fiscal Year
2008
Total Cost
$174,539
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Pratap, Jitesh; Akech, Jacqueline; Wixted, John J et al. (2010) The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther 9:3210-20
Becker, Klaus A; Ghule, Prachi N; Lian, Jane B et al. (2010) Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cells. J Cell Physiol 222:456-64
Guseva, Nina; Phillips, David; Mordes, John P (2010) Successful treatment of persistent hyperinsulinemic hypoglycemia with nifedipine in an adult patient. Endocr Pract 16:107-11
Becker, Klaus A; Stein, Janet L; Lian, Jane B et al. (2010) Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming. J Cell Physiol 222:103-10
Pfister, Edith L; Kennington, Lori; Straubhaar, Juerg et al. (2009) Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol 19:774-8
Rossini, Aldo A; Greiner, Dale L (2007) Diabetes research in jeopardy: the extinction of clinical diabetes researchers. Ann N Y Acad Sci 1103:33-44
Gaur, S; Yamaguchi, H; Goodman, H M (2000) Activation of the sodium pump blocks the growth hormone-induced increase in cytosolic free calcium in rat adipocytes. Endocrinology 141:513-9
Colzani, R M; Alex, S; Fang, S L et al. (1999) Effects of iodine repletion on thyroid morphology in iodine and/or selenium deficient rat term fetuses, pups and mothers. Biochimie 81:485-91
Colzani, R M; Alex, S; Dunn, A D et al. (1999) The oral administration of human thyroglobulin does not affect the incidence of lymphocytic thyroiditis in the biobreeding Worcester rat. Thyroid 9:831-5
Colzani, R; Fang, S L; Alex, S et al. (1998) The effect of nicotine on thyroid function in rats. Metabolism 47:154-7

Showing the most recent 10 out of 41 publications