This is a competitive renewal for our longstanding Training Program in Diabetes, Endocrinology and Metabolic Diseases. During the most recent funding cycle, 4 postdoctoral fellows were supported each year. A total of 11 trainees working in 9 different labs have been supported. The program is designed to accommodate both Ph.D. scientists as well as physician scientists with M.D. or M.D, Ph.D. degrees, of whom most enter through the Penn Clinical Fellowship Program in Endocrinology, Diabetes and Metabolism. Of the postdoctoral trainees supported by this T32 during the last 4 years who are no longer in training, one has a staff position at Merck, two have junior faculty positions at University of Pennsylvania and Long Island Jewish/Hofstra University, respectively and one is in private practice in an academic environment. For the next period, we request additional support to add one more fellow. We also request, for the first time, sufficient funds to support three predoctoral students working in the areas of this program during their third through fifth years of graduate school. At present, there are in laboratories directed by our trainers 29 students working towards their Ph.D. theses, the majority focusing on problems relevant to the mission of this T32 and unsupported by a training grants. Five (26%) are underrepresented minorities. Our 24 training faculty have primary appointments in seven Medical School Departments and consist of 14 professors, 7 associate professors, and assistant 3 professors. Six members of the training faculty are woman and one is African-American. In the last two funding cycles, six faculty members have been removed from the grant and twelve have been appointed to the training grant. Training grant faculty bring to the program expertise in 2-cell development and function, hormone action, physiology, diabetic complications, genetics in humans and model organisms, transcriptional regulation, patient oriented research, epidemiology and biostatistics. This training program continues to provide superb preparation for those scientists committed to careers in research into diabetes, endocrinology and metabolism.

Public Health Relevance

Obesity and diabetes mellitus are reaching epidemic proportions worldwide. In the United States alone, the estimated cost of diabetes in 2007 was $174 billion, including $116 billion in excess medical expenditures and $58 billion in reduced national productivity. The goal of this grant is to help train the next generation physician and basic researchers at the predoctoral and doctoral levels in research into the prevention and treatment of diabetes and other endocrine disorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
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University of Pennsylvania
Internal Medicine/Medicine
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United States
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Vajravelu, Mary Ellen; De León, Diva D (2018) Genetic characteristics of patients with congenital hyperinsulinism. Curr Opin Pediatr 30:568-575
Vajravelu, Mary Ellen; Chai, Jinghua; Krock, Bryan et al. (2018) Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2. J Clin Endocrinol Metab 103:1042-1047
Vajravelu, Mary Ellen; Keren, Ron; Weber, David R et al. (2018) Incidence and risk of celiac disease after type 1 diabetes: A population-based cohort study using the health improvement network database. Pediatr Diabetes 19:1422-1428
Herrera, Adriana; Vajravelu, Mary Ellen; Givler, Stephanie et al. (2018) Prevalence of Adverse Events in Children With Congenital Hyperinsulinism Treated With Diazoxide. J Clin Endocrinol Metab 103:4365-4372
Alhadeff, Amber L; Su, Zhenwei; Hernandez, Elen et al. (2018) A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell 173:140-152.e15
Rickels, Michael R; Peleckis, Amy J; Dalton-Bakes, Cornelia et al. (2018) Continuous Glucose Monitoring for Hypoglycemia Avoidance and Glucose Counterregulation in Long-Standing Type 1 Diabetes. J Clin Endocrinol Metab 103:105-114
Barrosse-Antle, Mary; Su, Chang; Chen, Pan et al. (2017) A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase. Pediatr Diabetes 18:911-916
Remsberg, Jarrett R; Ediger, Benjamin N; Ho, Wesley Y et al. (2017) Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion. Mol Metab 6:30-37
Rozo, Andrea V; Babu, Daniella A; Suen, PoMan A et al. (2017) Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture. Mol Metab 6:748-759
Su, Zhenwei; Alhadeff, Amber L; Betley, J Nicholas (2017) Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity. Cell Rep 21:2724-2736

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