Scientists at The Jackson Laboratory (TJL) have long seen the need to train a cadre of research scientists in the complexity of the genetic basis of immunological and hematological problems using intact animal model systems. This philosophy, an integral part of the Laboratory's Strategic Plan, has dictated the ongoing expansion of the overall training program at TJL. The Jackson Laboratory requests funding for continuation of its well-established postdoctoral research training program in immunology and hematology. Ten members of the TJL Research Staff form an interdisciplinary pool of trainee preceptors who are investigating gene regulation, cell development and math models in hemopoietic and immunological pathways in the mouse. Experimental work in genetically-defined animal models provides the opportunity to test hypotheses regarding the genetic basis of immunological and hematological disorders and to model new diagnostic and therapeutic modalities. These types of analyses are made possible by the availability of the Laboratory's unparalleled resource base of special inbred, spontaneous and induced-mutant mice. TJL Postdoctoral program (4 trainees). Trainees devote their major effort to bench research, and are integrated into TJL seminars, workshops, and research interest groups. They are required to write fellowship applications, and present their results both at in-house interest groups and international meetings. Their progress is overseen by a formal Training Committee, each member of which acts as an informal sub-mentor, or liaison, for several trainees. On completion of training, participants will be qualified to engage in creative, independent research in hematology and immunology at a university, research institution, or in industry. These well-trained scientists will be given the tools to unlock the mysteries of immunological and hematological diseases in mice, which could then solve the same problems in humans. The resultant knowledge will serve the public health interests by developing treatments for Type 1 diabetes, anemia, leukemia, stem cell defects, rheumatoid arthritis, and a host of other diseases. The primary training facility is TJL, a private, independent research center. TJL is an NIH Basic Cancer Research Center, raises 3 million mice annually, and has held NIH research training grants since 1956.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Bishop, Terry Rogers
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Jackson Laboratory
Bar Harbor
United States
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Pazdro, Robert; Harrison, David E (2013) Murine adipose tissue-derived stromal cell apoptosis and susceptibility to oxidative stress in vitro are regulated by genetic background. PLoS One 8:e61235
Rantala, Juha K; Pouwels, Jeroen; Pellinen, Teijo et al. (2011) SHARPIN is an endogenous inhibitor of ?1-integrin activation. Nat Cell Biol 13:1315-24
Hasham, Muneer G; Donghia, Nina M; Coffey, Eliot et al. (2010) Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11:820-6
Roopenian, Derry C; Sun, Victor Z (2010) Clinical ramifications of the MHC family Fc receptor FcRn. J Clin Immunol 30:790-7
Caddle, Lura B; Hasham, Muneer G; Schott, William H et al. (2008) Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol 28:2295-303
Ertl, Robin P; Chen, Jichun; Astle, Clinton M et al. (2008) Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood 111:1709-16
Sharma, Yashoda; Astle, Clinton M; Harrison, David E (2007) Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol 35:214-220
Johnson, Kenneth R; Gagnon, Leona H; Webb, Lisa S et al. (2003) Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene. Hum Mol Genet 12:3075-86
Brown 2nd, B A; Li, Y; Brown, J C et al. (1998) Isolation and characterization of a monoclonal anti-quadruplex DNA antibody from autoimmune ""viable motheaten"" mice. Biochemistry 37:16325-37
Kaysser, T M; Wandersee, N J; Bronson, R T et al. (1997) Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. Blood 90:4610-9

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