The overall purpose of this program is the training of new scientists capable of performing high quality biomedical research in the areas of diabetes, metabolism and insulin and growth factor action. The program is centered within the Division of Endocrinology and Metabolism of the Department of Medicine and includes 17 faculty participants. The faculty represent a range of interests, skills and approaches, ranging from basic research to c.linical investigation, all converging on the common themes of diabetes, metabolism and signal transduction. The proposed program will provide training opportunities at the postdoctoral level in either ba- sic or clinical research. The disciplines range from clinical diabetes, to clinical research, biochemistry, mo- lecular biology, cell biology and animal physiology. The program will include: (1) intensive laboratory and/or clinical research training, (2) seminars and other conferences, and (3) formal course instruction. The primary focus on the training program is the research undertaken by each trainee in association with a member of the training grant faculty. Under close supervi- sion by the faculty member, the trainee will be encouraged, and expected, to assume an increasingly inde- pendent scientific role in all aspects of the research. In addition, the training program will foster and encour- age a scholarly exchange of ideas and intellectual cross fertilization. Weekly seminars are held where ongo- ing research is presented for discussion by the group as a whole. Another weekly meeting is devoted to dis- cussions by training grant faculty and trainees of recent scientific advances. In part, this conference func- tions as a Journal Club. Finally, all trainees are required to take 4 quarters of formal course work, including a required course entitled """"""""Biomedical Research Ethics"""""""" offered through the School of Medicine. Thus, this training progr.am expands and brings together various activities encompassingthe training and education of postdoctoral fellows in the fields of diabetes, metabolism and signal transduction at the University of Califor- nia, San Diego School of Medicine.

Public Health Relevance

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007494-27S1
Application #
8070086
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1984-07-01
Project End
2014-06-30
Budget Start
2010-09-30
Budget End
2011-06-30
Support Year
27
Fiscal Year
2010
Total Cost
$15,865
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wortham, Matthew; Benthuysen, Jacqueline R; Wallace, Martina et al. (2018) Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ? Cell Function. Cell Rep 25:2904-2918.e8
Xie, Huimin; Hoffmann, Hanne M; Iyer, Anita K et al. (2017) Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15:86
Wortham, M; Sander, M (2016) Mechanisms of ?-cell functional adaptation to changes in workload. Diabetes Obes Metab 18 Suppl 1:78-86
Wang, Allen; Yue, Feng; Li, Yan et al. (2015) Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell 16:386-99
Franck, Niclas; Maris, Michael; Nalbandian, Sarah et al. (2014) Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PLoS One 9:e107487
Suh, Jae Myoung; Jonker, Johan W; Ahmadian, Maryam et al. (2014) Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature 513:436-9
Glidewell-Kenney, Christine A; Trang, Crystal; Shao, Paul P et al. (2014) Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology 155:3909-19
Lee, Yun Sok; Kim, Jung-whan; Osborne, Olivia et al. (2014) Increased adipocyte O2 consumption triggers HIF-1?, causing inflammation and insulin resistance in obesity. Cell 157:1339-52
Shih, Hung Ping; Wang, Allen; Sander, Maike (2013) Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol 29:81-105
Guo, Yurong; Darshi, Manjula; Ma, Yuliang et al. (2013) Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics 12:3744-58

Showing the most recent 10 out of 63 publications