This is a competing continuation application for the """"""""Hormones & Metabolism: Cells, Tissues, Animals & Humans"""""""" training grant, established originally in 1985. Our mission is to provide training at the pre- and post-doctoral levels for independent research careers in studying hormone biosynthesis, receptors, and signal transduction. In recent years, there has been major expansion of interest and recruitment at the school in areas relating to endocrinology-metabolism, obesity, and diabetes; this application reflects the continued trend to increase focus on these areas, while maintaining the successful infrastructure of our training program. Based on discussions with NIDDK program staff, our current proposal requests funding for 6 predoctoral and 4 postdoctoral positions. Predoctoral training will lead to a Ph.D. degree in the Sue Golding Graduate Division (including meeting formal coursework, qualifying exam, and dissertation research requirements, with one of our trainers as mentor in consultation with an advisory committee). Postdoctoral trainees (M.D. or Ph.D.) engage in full-time research for 1-3 years in a participating lab of a trainer; interactions with others of the training Program is through works-in-progress, journal clubs and seminars. Our faculty, as a group, are well-funded, investigators with strong training records, ranging from Assistant to Full Professor, engaged in multidisciplinary approaches which cover the most important areas of diabetes/metabolism/cell signaling research, specifically: 1) Regulation of Hormone Biosynthesis and Secretion (from gene expression to protein processing(Drs. Arvan, Carrasco, Fricker, Scherer, Shields)2) Hormone Receptor Expression, Structure, Function and Cellular Compartmentalization(Drs. Backer, Etgen, Lisanti, Pestell, Rubin, Stanley, Zukin)3) Signal Transduction Molecules, Effectors, and Pathways(Drs. Brownlee, Backer, Charron, Etgen, Lisanti, Pestell, Rossetti, Rubin, Shields, Stanley, Zukin)4) Pathways Regulating Body Metabolism and Disturbances in Obesity and Diabetes(Drs. Arvan, Brownlee, Carrasco, Charron, Fricker, Rossetti, Scherer) This program provides training in an area for which our institution has no other training grant support, namely interaction of hormones, receptors and signaling molecules.
| Scandiuzzi, Lisa; Ghosh, Kaya; Hofmeyer, Kimberly A et al. (2014) Tissue-expressed B7-H1 critically controls intestinal inflammation. Cell Rep 6:625-32 |
| Abadi, Yael M; Jeon, Hyungjun; Ohaegbulam, Kim C et al. (2013) Host b7x promotes pulmonary metastasis of breast cancer. J Immunol 190:3806-14 |
| Lee, Jun Sik; Scandiuzzi, Lisa; Ray, Anjana et al. (2012) B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 189:4165-74 |
| Israel, Davelene D; Sheffer-Babila, Sharone; de Luca, Carl et al. (2012) Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology 153:2408-19 |
| Hofmeyer, Kimberly A; Scandiuzzi, Lisa; Ghosh, Kaya et al. (2012) Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection. J Immunol 189:3054-63 |
| Hofmeyer, Kimberly A; Jeon, Hyungjun; Zang, Xingxing (2011) The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol 2011:451694 |
| Grove, Charlotte L; Szabo, Theresa M; McIntosh, J Michael et al. (2011) Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors. J Physiol 589:575-95 |
| Yang, Yupeng; Takeuchi, Koichi; Rodenas-Ruano, Alma et al. (2009) Developmental switch in requirement for PKA RIIbeta in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses. Neuropharmacology 56:56-65 |
| Khan, Tayeba; Muise, Eric S; Iyengar, Puneeth et al. (2009) Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29:1575-91 |
| Khan, Tayeba; Hamilton, Mark P; Mundy, Dorothy I et al. (2009) Impact of simvastatin on adipose tissue: pleiotropic effects in vivo. Endocrinology 150:5262-72 |
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