The Endocrine Training Program at Beth Israel Deaconess Medical Center, directed by Dr. Barbara Kahn, trains MD, MD/PhD and PhD postdoctoral candidates in the research areas of endocrinology, diabetes, and metabolism. The goal of the program is to foster the development of the next generation of trainees into independent investigators in endocrinology and metabolism, who will excel in scientific investigation and succeed in obtaining faculty positions in at major universities and medical schools. A secondary goal is to provide a rigorous scientific foundation for fellows who will go on to careers as clinician-educators. The research faculty for the endocrine program is an experienced group of investigators, all of whom are Harvard Medical School faculty members involved in the comprehensive study of obesity, diabetes, the metabolic syndrome, nuclear receptor action, neuroendocrinology and signal transduction. The faculty is comprised of basic scientists and clinical scientists who work together to train fellows to investigate research questions at the molecular and physiological levels. The collaborative nature of the faculty is evidenced by multiple joint publications and shared research core facilities as part of the Boston area NIH-funded Nutrition-Obesity Research Centers and Diabetes Endocrinology Research Centers. Trainees are provided an opportunity to learn from the collective expertise of the faculty in the areas of hormone action, regulation of gene expression, adipocyte biology, animal physiology, gene targeting approaches to endocrine and metabolic disorders, neuroanatomy and neurophysiology, research in human subjects, and strategies for novel treatment modalities. Our trainees have an outstanding record of obtaining independent funding and promotion to faculty positions. These funded investigators now participate in the training of fellows in this and other Programs in Endocrinology, Diabetes and Metabolism around the country. Since the last competitive renewal of this grant, the Division has added new, talented faculty and has expanded its research space and core facilities. In particular, the program is strongly supported by core facilities at Beth Israel Deaconess Medical Center in genomics, proteomics, metabolomics, mass spectrometry, flow cytometry, biostatistics and bioinformatics, and transgenic mouse generation. The program has further formalized its curriculum in the Responsible Conduct of Research. The success of the trainees reflects the outstanding quality of this Endocrine Training Program.

Public Health Relevance

The current epidemic of obesity and diabetes sweeping the American populace has heightened the need for well-trained academic endocrinologists who can address the problem with clinical, translational, and basic science approaches. The Endocrine Training Program at the Beth Israel Deaconess Medical Center has a long record of accomplishment in producing such scientists. The undiminished tide of metabolic disease underscores the importance of continuing the vital activities of this Training Program.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Beth Israel Deaconess Medical Center
United States
Zip Code
Ramesh, Rohan N; Burgess, Christian R; Sugden, Arthur U et al. (2018) Intermingled Ensembles in Visual Association Cortex Encode Stimulus Identity or Predicted Outcome. Neuron 100:900-915.e9
Kumar, Anil; Katz, Liora S; Schulz, Anna M et al. (2018) Activation of Nrf2 Is Required for Normal and ChREBP?-Augmented Glucose-Stimulated ?-Cell Proliferation. Diabetes 67:1561-1575
Liang, Liang; Fratzl, Alex; Goldey, Glenn et al. (2018) A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell 173:1343-1355.e24
Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4
Kim, MiSung; Astapova, Inna I; Flier, Sarah N et al. (2017) Intestinal, but not hepatic, ChREBP is required for fructose tolerance. JCI Insight 2:
Lee, Jennifer; Moraes-Vieira, Pedro M; Castoldi, Angela et al. (2016) Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem 291:22207-22217
Burgess, Christian R; Ramesh, Rohan N; Sugden, Arthur U et al. (2016) Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala. Neuron 91:1154-1169
Kim, Mi-Sung; Krawczyk, Sarah A; Doridot, Ludivine et al. (2016) ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest 126:4372-4386
Kang, Sona; Tsai, Linus T-Y; Rosen, Evan D (2016) Nuclear Mechanisms of Insulin Resistance. Trends Cell Biol 26:341-351
Singh, Brijesh K; Sinha, Rohit A; Zhou, Jin et al. (2016) Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem 291:198-214

Showing the most recent 10 out of 53 publications