This is a 5-year renewal application to support 5 postdoctoral trainees for a broad program in Academic Endocrinology. This program has been in place at the Brigham and Women's Hospital/Harvard Medical School since 1985 and has been highly successful in training physicians and basic scientists, many of whom remain in academic endocrinology. In the last 10 year period, 67% of the 18 trainees completing their training remain in a research career. The faculty combines both the physician-scientists of the Endocrinology Division with those basic scientists on the Harvard Medical School faculty whose research is significantly related to endocrinology. Over the last ten years, these 16 faculty individuals have trained over 300 postdoctoral fellows, over 95% of whom remain in research-related careers, either in academic positions or in industry. The faculty are well-funded, with estimated modified direct costs per annum of over $50 million. The 5 trainees appointed each year will be individuals with MD, PhD, or MD/PhD degrees and they will undertake 3-4 years of an intensive research experience in either basic or clinical investigation. The goal of the program is to provide the trainees with sufficient expertise to apply successfully for mentored research awards, such as K23, K08, or K01 awards, or R01 grants, when indicated. The areas of research interest of the faculty include regulation of energy expenditure, insulin sensitivity, mechanisms of calcium signaling, the role of the iodothyronine deiodinases in controlling differentiation and cell division via local activation and inactivation of thyroid hormone, the process of bone development and its clinical implications, the study of G-protein-coupled receptors, particularly in the hypothalamus, the control of skeletal muscle repair and mechanisms of muscle proteolysis in cachexia and muscle atrophy, the mechanisms of steroid hormone action and the epidemiology of diabetes, obesity, and vitamin D-deficiency disorders. Individuals in this program will also be trained to translate the insights they gain to develop strategies for the treatment and prevention of common endocrinology-based public health problems, including diabetes, obesity and osteoporosis.
This Endocrinology Training Program assembles a group of outstanding clinical and basic scientists to oversee the training of fellows with an interest in understanding the regulation and mechanism of hormone effects and how they are disrupted to produce clinical disorders. Fellows will be trained in either basic or clinical research techniques in order to contribute to the understanding and treatment of major endocrine-related disorders, such as obesity, diabetes, and osteoporosis.
|Stamatiades, George A; Ioannou, Petros; Petrikkos, George et al. (2018) Fungal infections in patients with inflammatory bowel disease: A systematic review. Mycoses 61:366-376|
|Stamatiades, George A; Kaiser, Ursula B (2018) Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression. Mol Cell Endocrinol 463:131-141|
|Kalliora, Charikleia; Mamoulakis, Charalampos; Vasilopoulos, Eleni et al. (2018) Association of pesticide exposure with human congenital abnormalities. Toxicol Appl Pharmacol 346:58-75|
|Papaioannou, Garyfallia; Petit, Elizabeth T; Liu, Eva S et al. (2017) Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem 292:3164-3171|
|Hatting, Maximilian; Rines, Amy K; Luo, Chi et al. (2017) Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting. Cell Metab 25:428-437|
|Wu, Elizabeth Y; Lebastchi, Jasmin; Marqusee, Ellen et al. (2017) A case of primary secretory carcinoma of the thyroid with high-grade features. Histopathology 71:665-669|
|Roberts, Stephanie A; Moon, Jennifer E; Dauber, Andrew et al. (2017) Novel germline mutation (Leu512Met) in the thyrotropin receptor gene (TSHR) leading to sporadic non-autoimmune hyperthyroidism. J Pediatr Endocrinol Metab 30:343-347|
|Liu, Xiaoyun; Medici, Marco; Kwong, Norra et al. (2016) Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis. Thyroid 26:256-61|
|Liu, Eva S; Raimann, Adalbert; Chae, Byongsoo Timothy et al. (2016) c-Raf promotes angiogenesis during normal growth plate maturation. Development 143:348-55|
|Kakarmath, Sujay; Heller, Howard T; Alexander, Caroline A et al. (2016) Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma. J Clin Endocrinol Metab 101:4938-4944|
Showing the most recent 10 out of 111 publications